Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death

Calcium (Ca2+) plays an important role as a messenger in the excitation-contraction coupling process of the myocardium. It is stored in the sarcoplasmic reticulum (SR) and released via a calcium release channel called the ryanodine receptor. Cardiac ryanodine receptor (RyR2) controls Ca2+ release, w...

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Main Authors: Phrommintikul A., Chattipakorn N.
Format: Review
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-33748446380&partnerID=40&md5=a2fc8b3aca816c3aa857f5caedfa66e2
http://www.ncbi.nlm.nih.gov/pubmed/16701909
http://cmuir.cmu.ac.th/handle/6653943832/2047
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-20472014-08-30T02:00:25Z Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death Phrommintikul A. Chattipakorn N. Calcium (Ca2+) plays an important role as a messenger in the excitation-contraction coupling process of the myocardium. It is stored in the sarcoplasmic reticulum (SR) and released via a calcium release channel called the ryanodine receptor. Cardiac ryanodine receptor (RyR2) controls Ca2+ release, which is essential for cardiac contractility. There are several molecules which bind and regulate the function of RyR2 including calstabin2, calmodulin, protein kinase A (PKA), phosphatase, sorcin and calsequestrin. Alteration of RyR2 and associated molecules can cause functional and/or structural changes of the heart, leading to heart failure and sudden cardiac death. In this review, the alteration of RyR2 and its regulatory proteins, and its roles in heart failure and sudden cardiac death, are discussed. Evidence of a possible novel therapy targeting RyR2 and its associated regulatory proteins, currently proposed by investigators, is also included in this article. © 2006 Elsevier Ireland Ltd. All rights reserved. 2014-08-30T02:00:25Z 2014-08-30T02:00:25Z 2006 Review 01675273 10.1016/j.ijcard.2005.11.106 16701909 IJCDD http://www.scopus.com/inward/record.url?eid=2-s2.0-33748446380&partnerID=40&md5=a2fc8b3aca816c3aa857f5caedfa66e2 http://www.ncbi.nlm.nih.gov/pubmed/16701909 http://cmuir.cmu.ac.th/handle/6653943832/2047 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Calcium (Ca2+) plays an important role as a messenger in the excitation-contraction coupling process of the myocardium. It is stored in the sarcoplasmic reticulum (SR) and released via a calcium release channel called the ryanodine receptor. Cardiac ryanodine receptor (RyR2) controls Ca2+ release, which is essential for cardiac contractility. There are several molecules which bind and regulate the function of RyR2 including calstabin2, calmodulin, protein kinase A (PKA), phosphatase, sorcin and calsequestrin. Alteration of RyR2 and associated molecules can cause functional and/or structural changes of the heart, leading to heart failure and sudden cardiac death. In this review, the alteration of RyR2 and its regulatory proteins, and its roles in heart failure and sudden cardiac death, are discussed. Evidence of a possible novel therapy targeting RyR2 and its associated regulatory proteins, currently proposed by investigators, is also included in this article. © 2006 Elsevier Ireland Ltd. All rights reserved.
format Review
author Phrommintikul A.
Chattipakorn N.
spellingShingle Phrommintikul A.
Chattipakorn N.
Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death
author_facet Phrommintikul A.
Chattipakorn N.
author_sort Phrommintikul A.
title Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death
title_short Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death
title_full Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death
title_fullStr Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death
title_full_unstemmed Roles of cardiac ryanodine receptor in heart failure and sudden cardiac death
title_sort roles of cardiac ryanodine receptor in heart failure and sudden cardiac death
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-33748446380&partnerID=40&md5=a2fc8b3aca816c3aa857f5caedfa66e2
http://www.ncbi.nlm.nih.gov/pubmed/16701909
http://cmuir.cmu.ac.th/handle/6653943832/2047
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