Bactericidal activity of M protein conserved region antibodies against group A streptococcal isolates from the Northern Thai population

• Main Authors: Yoonim N., Olive C., Pruksachatkunakorn C., Pruksakorn S.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-33748283932&partnerID=40&md5=9840118abc0db5b101e2a44ba8678dac; http://www.ncbi.nlm.nih.gov/pubmed/16895610; http://cmuir.cmu.ac.th/handle/6653943832/2056
• Institution: Chiang Mai University

Background: Most group A streptococcal (GAS) vaccine strategies have focused on the surface M protein, a major virulence factor of GAS. The amino-terminus of the M protein elicits antibodies, that are both opsonic and protective, but which are type specific. J14, a chimeric peptide that contains 14...