A successful strategy for Preimplantation Genetic Diagnosis of beta-thalassemia and simultaneous detection of Down's syndrome using multiplex fluorescent PCR

• Main Authors: Piyamongkol W., Vutyavanich T., Piyamongkol S., Wells D., Kunaviktikul C., Tongsong T., Chaovisitsaree S., Saetung R., Sanguansermsri T.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-33746211279&partnerID=40&md5=68afe9d21ecd66591073e5d57186557f; http://www.ncbi.nlm.nih.gov/pubmed/16881421; http://cmuir.cmu.ac.th/handle/6653943832/2075
• Institution: Chiang Mai University

Objectives: Preimplantation Genetic Diagnosis (PGD) is an alternative to prenatal diagnosis providing couples the chance to start a pregnancy with an unaffected fetus. The objective of the present study was to develop and apply quick, sensitive and accurate single cell PCR protocols for PGD of beta-...