Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates

Objective: To determine the pharmacological efficacy and safety of the gentamicin regimen that adjusts intravenous dose and interval based on the gestational age (GA) in Thai neonates. Material and Method: Neonates aged ≤ 7 days, who had received gentamicin for clinically suspected or high risk of s...

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Main Authors: Tantiprabha W., Juntarakana S., Chotinaruemol S., Rojanasthien N.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-38649111993&partnerID=40&md5=8da0a89e2ea0b8f4ba94a13612ea2d76
http://www.ncbi.nlm.nih.gov/pubmed/18386709
http://cmuir.cmu.ac.th/handle/6653943832/2094
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-20942014-08-30T02:00:28Z Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates Tantiprabha W. Juntarakana S. Chotinaruemol S. Rojanasthien N. Objective: To determine the pharmacological efficacy and safety of the gentamicin regimen that adjusts intravenous dose and interval based on the gestational age (GA) in Thai neonates. Material and Method: Neonates aged ≤ 7 days, who had received gentamicin for clinically suspected or high risk of sepsis and had no contraindication to gentamicin usage were enrolled. They were stratified into four groups by GA as ≤ 29, 30-33, 34-37 and ≥ 38 weeks gestation. Gentamicin administration in each group was 5, 4.5, 4 and 4 mg/kg/dose every 48, 36, 36 and 24 hours respectively according to Neofax □ regimen. Peak serum gentamicin concentration (SGC), trough SGC and serum creatinine (Cr) were obtained. Results: Forty-nine neonates were enrolled. Forty-four (89.7%) had peak SGC within the desirable range (5-12 mg/L). Three neonates had slightly high peak SGC. Their peak SGCs were 13.0, 12.21 and 12.20 mg/L. Two neonates had slightly low peak SGC. Their peak SGCs were 4.91 and 4.4 mg/L. All neonates had trough SGC below 2 mg/L. None had significant rising of serum Cr during the present study period. Conclusion: This gentamicin regimen yielded good pharmacological efficacy and safety in Thai neonates, who were in the first week of life and had no renal function impairment. 2014-08-30T02:00:28Z 2014-08-30T02:00:28Z 2007 Article 01252208 18386709 JMTHB http://www.scopus.com/inward/record.url?eid=2-s2.0-38649111993&partnerID=40&md5=8da0a89e2ea0b8f4ba94a13612ea2d76 http://www.ncbi.nlm.nih.gov/pubmed/18386709 http://cmuir.cmu.ac.th/handle/6653943832/2094 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Objective: To determine the pharmacological efficacy and safety of the gentamicin regimen that adjusts intravenous dose and interval based on the gestational age (GA) in Thai neonates. Material and Method: Neonates aged ≤ 7 days, who had received gentamicin for clinically suspected or high risk of sepsis and had no contraindication to gentamicin usage were enrolled. They were stratified into four groups by GA as ≤ 29, 30-33, 34-37 and ≥ 38 weeks gestation. Gentamicin administration in each group was 5, 4.5, 4 and 4 mg/kg/dose every 48, 36, 36 and 24 hours respectively according to Neofax □ regimen. Peak serum gentamicin concentration (SGC), trough SGC and serum creatinine (Cr) were obtained. Results: Forty-nine neonates were enrolled. Forty-four (89.7%) had peak SGC within the desirable range (5-12 mg/L). Three neonates had slightly high peak SGC. Their peak SGCs were 13.0, 12.21 and 12.20 mg/L. Two neonates had slightly low peak SGC. Their peak SGCs were 4.91 and 4.4 mg/L. All neonates had trough SGC below 2 mg/L. None had significant rising of serum Cr during the present study period. Conclusion: This gentamicin regimen yielded good pharmacological efficacy and safety in Thai neonates, who were in the first week of life and had no renal function impairment.
format Article
author Tantiprabha W.
Juntarakana S.
Chotinaruemol S.
Rojanasthien N.
spellingShingle Tantiprabha W.
Juntarakana S.
Chotinaruemol S.
Rojanasthien N.
Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates
author_facet Tantiprabha W.
Juntarakana S.
Chotinaruemol S.
Rojanasthien N.
author_sort Tantiprabha W.
title Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates
title_short Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates
title_full Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates
title_fullStr Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates
title_full_unstemmed Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates
title_sort efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in thai neonates
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-38649111993&partnerID=40&md5=8da0a89e2ea0b8f4ba94a13612ea2d76
http://www.ncbi.nlm.nih.gov/pubmed/18386709
http://cmuir.cmu.ac.th/handle/6653943832/2094
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