Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates
Objective: To determine the pharmacological efficacy and safety of the gentamicin regimen that adjusts intravenous dose and interval based on the gestational age (GA) in Thai neonates. Material and Method: Neonates aged ≤ 7 days, who had received gentamicin for clinically suspected or high risk of s...
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th-cmuir.6653943832-20942014-08-30T02:00:28Z Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates Tantiprabha W. Juntarakana S. Chotinaruemol S. Rojanasthien N. Objective: To determine the pharmacological efficacy and safety of the gentamicin regimen that adjusts intravenous dose and interval based on the gestational age (GA) in Thai neonates. Material and Method: Neonates aged ≤ 7 days, who had received gentamicin for clinically suspected or high risk of sepsis and had no contraindication to gentamicin usage were enrolled. They were stratified into four groups by GA as ≤ 29, 30-33, 34-37 and ≥ 38 weeks gestation. Gentamicin administration in each group was 5, 4.5, 4 and 4 mg/kg/dose every 48, 36, 36 and 24 hours respectively according to Neofax □ regimen. Peak serum gentamicin concentration (SGC), trough SGC and serum creatinine (Cr) were obtained. Results: Forty-nine neonates were enrolled. Forty-four (89.7%) had peak SGC within the desirable range (5-12 mg/L). Three neonates had slightly high peak SGC. Their peak SGCs were 13.0, 12.21 and 12.20 mg/L. Two neonates had slightly low peak SGC. Their peak SGCs were 4.91 and 4.4 mg/L. All neonates had trough SGC below 2 mg/L. None had significant rising of serum Cr during the present study period. Conclusion: This gentamicin regimen yielded good pharmacological efficacy and safety in Thai neonates, who were in the first week of life and had no renal function impairment. 2014-08-30T02:00:28Z 2014-08-30T02:00:28Z 2007 Article 01252208 18386709 JMTHB http://www.scopus.com/inward/record.url?eid=2-s2.0-38649111993&partnerID=40&md5=8da0a89e2ea0b8f4ba94a13612ea2d76 http://www.ncbi.nlm.nih.gov/pubmed/18386709 http://cmuir.cmu.ac.th/handle/6653943832/2094 English |
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Objective: To determine the pharmacological efficacy and safety of the gentamicin regimen that adjusts intravenous dose and interval based on the gestational age (GA) in Thai neonates. Material and Method: Neonates aged ≤ 7 days, who had received gentamicin for clinically suspected or high risk of sepsis and had no contraindication to gentamicin usage were enrolled. They were stratified into four groups by GA as ≤ 29, 30-33, 34-37 and ≥ 38 weeks gestation. Gentamicin administration in each group was 5, 4.5, 4 and 4 mg/kg/dose every 48, 36, 36 and 24 hours respectively according to Neofax □ regimen. Peak serum gentamicin concentration (SGC), trough SGC and serum creatinine (Cr) were obtained. Results: Forty-nine neonates were enrolled. Forty-four (89.7%) had peak SGC within the desirable range (5-12 mg/L). Three neonates had slightly high peak SGC. Their peak SGCs were 13.0, 12.21 and 12.20 mg/L. Two neonates had slightly low peak SGC. Their peak SGCs were 4.91 and 4.4 mg/L. All neonates had trough SGC below 2 mg/L. None had significant rising of serum Cr during the present study period. Conclusion: This gentamicin regimen yielded good pharmacological efficacy and safety in Thai neonates, who were in the first week of life and had no renal function impairment. |
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Article |
author |
Tantiprabha W. Juntarakana S. Chotinaruemol S. Rojanasthien N. |
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Tantiprabha W. Juntarakana S. Chotinaruemol S. Rojanasthien N. Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates |
author_facet |
Tantiprabha W. Juntarakana S. Chotinaruemol S. Rojanasthien N. |
author_sort |
Tantiprabha W. |
title |
Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates |
title_short |
Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates |
title_full |
Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates |
title_fullStr |
Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates |
title_full_unstemmed |
Efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in Thai neonates |
title_sort |
efficacy and safety of gentamicin by interval and intravenous dosage adjustment based on the gestational age in thai neonates |
publishDate |
2014 |
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http://www.scopus.com/inward/record.url?eid=2-s2.0-38649111993&partnerID=40&md5=8da0a89e2ea0b8f4ba94a13612ea2d76 http://www.ncbi.nlm.nih.gov/pubmed/18386709 http://cmuir.cmu.ac.th/handle/6653943832/2094 |
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