Diagnostic level of cardiac troponin T in patients with chronic renal dysfunction, a pilot study

Objective: To find the diagnostic level and rising pattern of cardiac troponin T (cTnT) in patients with chronic renal dysfunction presented with acute myocardial infarction (AMI). Material and Method: A pilot, cross-sectional study to compare the level of cTnT in adult patients with chronic renal d...

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Main Authors: Sukonthasarn A., Ponglopisit S.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-35848967007&partnerID=40&md5=b78c2a47c875b41383270ec73b70922c
http://www.ncbi.nlm.nih.gov/pubmed/17957915
http://cmuir.cmu.ac.th/handle/6653943832/2156
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-21562014-08-30T02:00:32Z Diagnostic level of cardiac troponin T in patients with chronic renal dysfunction, a pilot study Sukonthasarn A. Ponglopisit S. Objective: To find the diagnostic level and rising pattern of cardiac troponin T (cTnT) in patients with chronic renal dysfunction presented with acute myocardial infarction (AMI). Material and Method: A pilot, cross-sectional study to compare the level of cTnT in adult patients with chronic renal dysfunction who were admitted and later confirmed to have AMI with those in the age and sex-matched controls with chronic renal dysfunction and non-coronary diagnosis. Results: Twenty-three patients were enrolled into each group. The mean cTnT levels in the AMI group were significantly higher than in the control group. Magnitude and rate of post-admission rise of cTnT were not significantly different between both groups. The diagnostic level of cTnT for AMI was 0.1 nanogram per milliliter with 90.90% sensitivity and 84.50% specificity. The sensitivity and specificity of this diagnostic level were 91.30% and 100.00% respectively when patients with chronic renal replacement were excluded. Conclusion: The level of cTnT of at least 0.1 nanogram per milliliter within the first 24 hours of admission was diagnostic for AMI in patients with chronic renal dysfunction. The sensitivity and specificity of the tests were better if the patients with chronic renal replacement were excluded. 2014-08-30T02:00:32Z 2014-08-30T02:00:32Z 2007 Article 01252208 17957915 JMTHB http://www.scopus.com/inward/record.url?eid=2-s2.0-35848967007&partnerID=40&md5=b78c2a47c875b41383270ec73b70922c http://www.ncbi.nlm.nih.gov/pubmed/17957915 http://cmuir.cmu.ac.th/handle/6653943832/2156 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Objective: To find the diagnostic level and rising pattern of cardiac troponin T (cTnT) in patients with chronic renal dysfunction presented with acute myocardial infarction (AMI). Material and Method: A pilot, cross-sectional study to compare the level of cTnT in adult patients with chronic renal dysfunction who were admitted and later confirmed to have AMI with those in the age and sex-matched controls with chronic renal dysfunction and non-coronary diagnosis. Results: Twenty-three patients were enrolled into each group. The mean cTnT levels in the AMI group were significantly higher than in the control group. Magnitude and rate of post-admission rise of cTnT were not significantly different between both groups. The diagnostic level of cTnT for AMI was 0.1 nanogram per milliliter with 90.90% sensitivity and 84.50% specificity. The sensitivity and specificity of this diagnostic level were 91.30% and 100.00% respectively when patients with chronic renal replacement were excluded. Conclusion: The level of cTnT of at least 0.1 nanogram per milliliter within the first 24 hours of admission was diagnostic for AMI in patients with chronic renal dysfunction. The sensitivity and specificity of the tests were better if the patients with chronic renal replacement were excluded.
format Article
author Sukonthasarn A.
Ponglopisit S.
spellingShingle Sukonthasarn A.
Ponglopisit S.
Diagnostic level of cardiac troponin T in patients with chronic renal dysfunction, a pilot study
author_facet Sukonthasarn A.
Ponglopisit S.
author_sort Sukonthasarn A.
title Diagnostic level of cardiac troponin T in patients with chronic renal dysfunction, a pilot study
title_short Diagnostic level of cardiac troponin T in patients with chronic renal dysfunction, a pilot study
title_full Diagnostic level of cardiac troponin T in patients with chronic renal dysfunction, a pilot study
title_fullStr Diagnostic level of cardiac troponin T in patients with chronic renal dysfunction, a pilot study
title_full_unstemmed Diagnostic level of cardiac troponin T in patients with chronic renal dysfunction, a pilot study
title_sort diagnostic level of cardiac troponin t in patients with chronic renal dysfunction, a pilot study
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-35848967007&partnerID=40&md5=b78c2a47c875b41383270ec73b70922c
http://www.ncbi.nlm.nih.gov/pubmed/17957915
http://cmuir.cmu.ac.th/handle/6653943832/2156
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