A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients

In 9 study centers, 419 patients with asthma or COPD were randomized to receive two forms of salbutamol metered-dose-inhalers (MDIs), i.e. CFC-driven MDI, non-CFC (HFA) MDI and one salbutamol dry powder inhaler (DPI), in a multi-center, comparative, cross-over and randomized study, performed to faci...

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Main Authors: Bunnag C., Fuangtong R., Pothirat C., Punyaratabandhu P.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-36049018912&partnerID=40&md5=1799442c2d8cc6a4d3ea084d50470dcb
http://cmuir.cmu.ac.th/handle/6653943832/2203
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-22032014-08-30T02:00:35Z A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients Bunnag C. Fuangtong R. Pothirat C. Punyaratabandhu P. In 9 study centers, 419 patients with asthma or COPD were randomized to receive two forms of salbutamol metered-dose-inhalers (MDIs), i.e. CFC-driven MDI, non-CFC (HFA) MDI and one salbutamol dry powder inhaler (DPI), in a multi-center, comparative, cross-over and randomized study, performed to facilitate the formulation of a strategic plan to phase out CFC MDIs. After having received all three forms of test products, the patients completed an evaluation questionnaire indicating their preferences, likelihood of treatment compliance on each product and the easiest one to use. Statistical analysis showed that the CFC MDI was significantly less irritating (p < 0.014) but lower in its overall appeal (p < 0.0001). The "most preferred form to be prescribed" was DPI at 47.5% followed by non-CFC at 32.5% and CFG MDI at 20.1 %. Concerning the ease of use among the three forms of test products, 59.9% of the patients indicated "no difference". Adverse events were mild and occurred in only 8.2%. In conclusion, patients' preference and sensory perception among the three forms of inhalers were comparable except that the CFC MDI was significantly less irritating but lower in its overall appeal. DPI was the most preferred and easiest form to use but also the most expensive. Taking public health into consideration, a non-CFC MDI with a similar market price to the CFC MDI would be the obvious choice in a strategic plan to phase out CFC MDIs with the least difficulty to the consumers. 2014-08-30T02:00:35Z 2014-08-30T02:00:35Z 2007 Article 0125877X 18035796 APJIE http://www.scopus.com/inward/record.url?eid=2-s2.0-36049018912&partnerID=40&md5=1799442c2d8cc6a4d3ea084d50470dcb http://cmuir.cmu.ac.th/handle/6653943832/2203 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description In 9 study centers, 419 patients with asthma or COPD were randomized to receive two forms of salbutamol metered-dose-inhalers (MDIs), i.e. CFC-driven MDI, non-CFC (HFA) MDI and one salbutamol dry powder inhaler (DPI), in a multi-center, comparative, cross-over and randomized study, performed to facilitate the formulation of a strategic plan to phase out CFC MDIs. After having received all three forms of test products, the patients completed an evaluation questionnaire indicating their preferences, likelihood of treatment compliance on each product and the easiest one to use. Statistical analysis showed that the CFC MDI was significantly less irritating (p < 0.014) but lower in its overall appeal (p < 0.0001). The "most preferred form to be prescribed" was DPI at 47.5% followed by non-CFC at 32.5% and CFG MDI at 20.1 %. Concerning the ease of use among the three forms of test products, 59.9% of the patients indicated "no difference". Adverse events were mild and occurred in only 8.2%. In conclusion, patients' preference and sensory perception among the three forms of inhalers were comparable except that the CFC MDI was significantly less irritating but lower in its overall appeal. DPI was the most preferred and easiest form to use but also the most expensive. Taking public health into consideration, a non-CFC MDI with a similar market price to the CFC MDI would be the obvious choice in a strategic plan to phase out CFC MDIs with the least difficulty to the consumers.
format Article
author Bunnag C.
Fuangtong R.
Pothirat C.
Punyaratabandhu P.
spellingShingle Bunnag C.
Fuangtong R.
Pothirat C.
Punyaratabandhu P.
A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients
author_facet Bunnag C.
Fuangtong R.
Pothirat C.
Punyaratabandhu P.
author_sort Bunnag C.
title A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients
title_short A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients
title_full A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients
title_fullStr A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients
title_full_unstemmed A comparative study of patients' preferences and sensory perceptions of three forms of inhalers among Thai asthma and COPD patients
title_sort comparative study of patients' preferences and sensory perceptions of three forms of inhalers among thai asthma and copd patients
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-36049018912&partnerID=40&md5=1799442c2d8cc6a4d3ea084d50470dcb
http://cmuir.cmu.ac.th/handle/6653943832/2203
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