Comparative in silico analysis of two vaccine candidates for group A streptococcus predicts that they both may have similar safety profiles

• Main Authors: Shaila M.S., Nayak R., Prakash S.S., Georgousakis M., Brandt E., McMillan D.J., Batzloff M.R., Pruksakorn S., Good M.F., Sriprakash K.S.
• 格式: Article
• 語言: English
• 出版: 2014
• 在線閱讀: http://www.scopus.com/inward/record.url?eid=2-s2.0-34147191723&partnerID=40&md5=4a798aec9f7452ca61009c10a04c2d99; http://cmuir.cmu.ac.th/handle/6653943832/2212
• 機構: Chiang Mai University

Background: Concerns of immune cross-reactivity, between epitopes of the group A streptococcal (GAS) M-proteins and host proteins have hindered the progress of an effective GAS vaccine. An ideal M-protein based subunit vaccine should not elicit heart tissue cross-reactive antibody responses and shou...