HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE

HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE

Molecular characterization of C2-V5 envelope sequences from maternal plasma, peripheral blood mononuclear cells (PBMC), cervical secretions and infant PBMC was performed in eight CRF01_AE-infected mother/infant pairs. Maternal viruses were relatively homogeneous within a compartment but distinct in...

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Main Authors: Tovanabutra S., De Souza M., Sittisombut N., Sriplienchan S., Ketsararat V., Birx D.L., Khamboonrueng C., Nelson K.E., McCutchan F.E., Robb M.L.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-34247603948&partnerID=40&md5=a7df1bd1c238d17921d2e311d8cd5821
http://cmuir.cmu.ac.th/handle/6653943832/2227
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-22272014-08-30T02:00:37Z HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE Tovanabutra S. De Souza M. Sittisombut N. Sriplienchan S. Ketsararat V. Birx D.L. Khamboonrueng C. Nelson K.E. McCutchan F.E. Robb M.L. Molecular characterization of C2-V5 envelope sequences from maternal plasma, peripheral blood mononuclear cells (PBMC), cervical secretions and infant PBMC was performed in eight CRF01_AE-infected mother/infant pairs. Maternal viruses were relatively homogeneous within a compartment but distinct in different compartments in mothers with high CD4 cell counts. Infant viruses were almost distinct, but phylogenetically related, to maternal viruses, mostly from the maternal PBMC compartment, reflecting the frequent transmission of HIV-1 from maternal cells rather than free viruses. © 2007 Lippincott Williams & Wilkins, Inc. 2014-08-30T02:00:37Z 2014-08-30T02:00:37Z 2007 Article 02699370 10.1097/QAD.0b013e32810c8cf3 17457103 AIDSE http://www.scopus.com/inward/record.url?eid=2-s2.0-34247603948&partnerID=40&md5=a7df1bd1c238d17921d2e311d8cd5821 http://cmuir.cmu.ac.th/handle/6653943832/2227 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Molecular characterization of C2-V5 envelope sequences from maternal plasma, peripheral blood mononuclear cells (PBMC), cervical secretions and infant PBMC was performed in eight CRF01_AE-infected mother/infant pairs. Maternal viruses were relatively homogeneous within a compartment but distinct in different compartments in mothers with high CD4 cell counts. Infant viruses were almost distinct, but phylogenetically related, to maternal viruses, mostly from the maternal PBMC compartment, reflecting the frequent transmission of HIV-1 from maternal cells rather than free viruses. © 2007 Lippincott Williams & Wilkins, Inc.
format Article
author Tovanabutra S.
De Souza M.
Sittisombut N.
Sriplienchan S.
Ketsararat V.
Birx D.L.
Khamboonrueng C.
Nelson K.E.
McCutchan F.E.
Robb M.L.
spellingShingle Tovanabutra S.
De Souza M.
Sittisombut N.
Sriplienchan S.
Ketsararat V.
Birx D.L.
Khamboonrueng C.
Nelson K.E.
McCutchan F.E.
Robb M.L.
HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE
author_facet Tovanabutra S.
De Souza M.
Sittisombut N.
Sriplienchan S.
Ketsararat V.
Birx D.L.
Khamboonrueng C.
Nelson K.E.
McCutchan F.E.
Robb M.L.
author_sort Tovanabutra S.
title HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE
title_short HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE
title_full HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE
title_fullStr HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE
title_full_unstemmed HIV-1 genetic diversity and compartmentalization in mother/infant pairs infected with CRF01_AE
title_sort hiv-1 genetic diversity and compartmentalization in mother/infant pairs infected with crf01_ae
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-34247603948&partnerID=40&md5=a7df1bd1c238d17921d2e311d8cd5821
http://cmuir.cmu.ac.th/handle/6653943832/2227
_version_ 1681419819006558208

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