Predictors of renal involvement in patients with systemic lupus erythematosus

• Main Authors: Satirapoj B., Wongchinsri J., Youngprang N., Laonapaporn B., Thongdee C., Lapkittichareonchai S., Patumanond J.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-34250890675&partnerID=40&md5=7366c035b9b46455f017a2a8d8e612f8; http://cmuir.cmu.ac.th/handle/6653943832/2246
• Institution: Chiang Mai University

From a cohort of 109 patients (105 females and 4 males) treated for systemic lupus erythematosus (SLE), 20 patients (18.3%) developed new episodes of lupus nephritis and 89 patients (81.7%) remained free of renal involvement during the follow-up period. The mean duration of follow up was 39.1 ± 54.4 months. Clinical characteristics associated with developing lupus nephritis were a high systolic blood pressure (≥ 130 mmHg), photosensitivity, cutaneous vasculitis and gastrointestinal (GI) symptoms. Laboratory abnormalities associated with the development of lupus nephritis were hemoglobin < 10 mg/dl, hematocrit < 30%, blood urea nitrogen > 12 mg/dl, serum creatinine > 1.3 mg/dl, ESR > 60, the third component of complement (C3) level < 0.45 and positive anti-dsDNA antibody. After a multivariable analysis, only high systolic blood pressure, cutaneous vasculitis, hemoglobin < 10 mg/dl and serum creatinine > 1.3 mg/dl remained as statistically significant risk factors for developing lupus nephritis.