Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy

Purpose: Hypercholesterolemia is a critical problem in patients with carotid atherosclerosis. The adequacy of attention to lipid risk factors in patients with carotid stenosis awaiting carotid endarterectomy (CEA) has rarely been studied. We also assessed patient awareness of hypercholesterolemia an...

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Main Authors: Rerkasem K., Gallagher P.J., Grimble R.F., Calder P.C., Shearman C.P.
Format: Review
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-60249083673&partnerID=40&md5=be95044e63ff3b5ab5a174a5632e7c2a
http://www.ncbi.nlm.nih.gov/pubmed/19337539
http://cmuir.cmu.ac.th/handle/6653943832/2301
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-23012014-08-30T02:00:41Z Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy Rerkasem K. Gallagher P.J. Grimble R.F. Calder P.C. Shearman C.P. Purpose: Hypercholesterolemia is a critical problem in patients with carotid atherosclerosis. The adequacy of attention to lipid risk factors in patients with carotid stenosis awaiting carotid endarterectomy (CEA) has rarely been studied. We also assessed patient awareness of hypercholesterolemia and carotid plaque morphology. Methods: A prospective study was conducted of 141 consecutive patients admitted electively for CEA. Each patient's medical history was taken. Plasma cholesterol concentrations were determined. Plaque histology was scored according to American Heart Association criteria and their modification. Results: Of patients who were aware of their hypercholesterolemia and who were receiving treatment, 28.6% had total cholesterol levels ≥5 mmol/L. Among those patients who had been told that they had no problem with hypercholesterolemia, 32.5% had plasma cholesterol concentrations ≥5 mmol/L. Among those patients who had never had their plasma cholesterol measured, 48.4% had total cholesterol levels ≥5 mmol/L. Patients in this last group tended to have more severe types of plaque pathology than those in other groups (12.9% plaque rupture). Conclusions: Hypercholesterolemia does not seem to be well managed in patients awaiting CEA. © 2008 Rerkasem et al, publisher and licensee Dove Medical Press Ltd. 2014-08-30T02:00:41Z 2014-08-30T02:00:41Z 2008 Review 11766344 19337539 http://www.scopus.com/inward/record.url?eid=2-s2.0-60249083673&partnerID=40&md5=be95044e63ff3b5ab5a174a5632e7c2a http://www.ncbi.nlm.nih.gov/pubmed/19337539 http://cmuir.cmu.ac.th/handle/6653943832/2301 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Purpose: Hypercholesterolemia is a critical problem in patients with carotid atherosclerosis. The adequacy of attention to lipid risk factors in patients with carotid stenosis awaiting carotid endarterectomy (CEA) has rarely been studied. We also assessed patient awareness of hypercholesterolemia and carotid plaque morphology. Methods: A prospective study was conducted of 141 consecutive patients admitted electively for CEA. Each patient's medical history was taken. Plasma cholesterol concentrations were determined. Plaque histology was scored according to American Heart Association criteria and their modification. Results: Of patients who were aware of their hypercholesterolemia and who were receiving treatment, 28.6% had total cholesterol levels ≥5 mmol/L. Among those patients who had been told that they had no problem with hypercholesterolemia, 32.5% had plasma cholesterol concentrations ≥5 mmol/L. Among those patients who had never had their plasma cholesterol measured, 48.4% had total cholesterol levels ≥5 mmol/L. Patients in this last group tended to have more severe types of plaque pathology than those in other groups (12.9% plaque rupture). Conclusions: Hypercholesterolemia does not seem to be well managed in patients awaiting CEA. © 2008 Rerkasem et al, publisher and licensee Dove Medical Press Ltd.
format Review
author Rerkasem K.
Gallagher P.J.
Grimble R.F.
Calder P.C.
Shearman C.P.
spellingShingle Rerkasem K.
Gallagher P.J.
Grimble R.F.
Calder P.C.
Shearman C.P.
Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy
author_facet Rerkasem K.
Gallagher P.J.
Grimble R.F.
Calder P.C.
Shearman C.P.
author_sort Rerkasem K.
title Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy
title_short Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy
title_full Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy
title_fullStr Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy
title_full_unstemmed Managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy
title_sort managing hypercholesterolemia and its correlation with carotid plaque morphology in patients undergoing carotid endarterectomy
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-60249083673&partnerID=40&md5=be95044e63ff3b5ab5a174a5632e7c2a
http://www.ncbi.nlm.nih.gov/pubmed/19337539
http://cmuir.cmu.ac.th/handle/6653943832/2301
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