A short amino acid sequence containing tyrosine in the N-terminal region of G protein-coupled receptors is critical for their potential use as coreceptors for human and simian immunodeficiency viruses

• Main Authors: Shimizu N., Tanaka A., Oue A., Mori T., Apichartpiyakul C., Hoshino H.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-58149388460&partnerID=40&md5=f7d6d191cfd5e5a7f7333292ed0dd1e9; http://cmuir.cmu.ac.th/handle/6653943832/2303
• Institution: Chiang Mai University

Various G protein-coupled receptors (GPCRs) have the potential to work as co-receptors for human and simian immunodeficiency virus (HIV/SIV). HIV/SIV co-receptors have several tyrosines in their extracellular N-terminal region (NTR) as a common feature. However, the domain structure of the NTR that...