Bioequivalence study of generic acyclovir compared with the brand name acyclovir®

The bioequivalence study of 200-mg generic acyclovir was conducted in healthy males. The reference Zovirax® and the test Zevin® were administered as a single oral dose after an overnight fast in a two-period, crossover design separated by 1 week. Serial blood samples were collected over a period of...

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Main Authors: Rojanasthien N., Kumsorn B., Hay Y.K., Teekachunhatean S., Chaichana N.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-0036823168&partnerID=40&md5=4221878ec81cebc30a30b30dc0ed49d3
http://cmuir.cmu.ac.th/handle/6653943832/2305
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-23052014-08-30T02:00:42Z Bioequivalence study of generic acyclovir compared with the brand name acyclovir® Rojanasthien N. Kumsorn B. Hay Y.K. Teekachunhatean S. Chaichana N. The bioequivalence study of 200-mg generic acyclovir was conducted in healthy males. The reference Zovirax® and the test Zevin® were administered as a single oral dose after an overnight fast in a two-period, crossover design separated by 1 week. Serial blood samples were collected over a period of 24 hours. Plasma acyclovir concentrations were determined by HPLC and the pharmacokinetic parameters were analyzed by non-compartmental analysis. Results: The t1/2 for the test (4.5 ± 2.4 h) and Zovirax® (3.9 ± 2.6 h) were comparable. The analysis of variance was carried out and the median Tmax (1.50 h) for the test was not statistically difference from Zovirax®. The mean (90% Cl) of the AUC0∞ and the Cmax] ratios for (Test/Reference) were 0.95 (0.83 - 1.09) and 0.95 (0.83 - 1.10), respectively. These values fell within the bioequivalence criteria of 0.80 - 1.25, thus it was concluded that Zevin® and Zovirax® were bioequivalence. 2014-08-30T02:00:42Z 2014-08-30T02:00:42Z 2002 Article 01252208 12501905 JMTHB http://www.scopus.com/inward/record.url?eid=2-s2.0-0036823168&partnerID=40&md5=4221878ec81cebc30a30b30dc0ed49d3 http://cmuir.cmu.ac.th/handle/6653943832/2305 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description The bioequivalence study of 200-mg generic acyclovir was conducted in healthy males. The reference Zovirax® and the test Zevin® were administered as a single oral dose after an overnight fast in a two-period, crossover design separated by 1 week. Serial blood samples were collected over a period of 24 hours. Plasma acyclovir concentrations were determined by HPLC and the pharmacokinetic parameters were analyzed by non-compartmental analysis. Results: The t1/2 for the test (4.5 ± 2.4 h) and Zovirax® (3.9 ± 2.6 h) were comparable. The analysis of variance was carried out and the median Tmax (1.50 h) for the test was not statistically difference from Zovirax®. The mean (90% Cl) of the AUC0∞ and the Cmax] ratios for (Test/Reference) were 0.95 (0.83 - 1.09) and 0.95 (0.83 - 1.10), respectively. These values fell within the bioequivalence criteria of 0.80 - 1.25, thus it was concluded that Zevin® and Zovirax® were bioequivalence.
format Article
author Rojanasthien N.
Kumsorn B.
Hay Y.K.
Teekachunhatean S.
Chaichana N.
spellingShingle Rojanasthien N.
Kumsorn B.
Hay Y.K.
Teekachunhatean S.
Chaichana N.
Bioequivalence study of generic acyclovir compared with the brand name acyclovir®
author_facet Rojanasthien N.
Kumsorn B.
Hay Y.K.
Teekachunhatean S.
Chaichana N.
author_sort Rojanasthien N.
title Bioequivalence study of generic acyclovir compared with the brand name acyclovir®
title_short Bioequivalence study of generic acyclovir compared with the brand name acyclovir®
title_full Bioequivalence study of generic acyclovir compared with the brand name acyclovir®
title_fullStr Bioequivalence study of generic acyclovir compared with the brand name acyclovir®
title_full_unstemmed Bioequivalence study of generic acyclovir compared with the brand name acyclovir®
title_sort bioequivalence study of generic acyclovir compared with the brand name acyclovir®
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-0036823168&partnerID=40&md5=4221878ec81cebc30a30b30dc0ed49d3
http://cmuir.cmu.ac.th/handle/6653943832/2305
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