Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells
Kaempferia parviflora Wall. ex. Baker is a Thai herb containing many flavonoids that have anti-inflammatory, anti-allergic and antioxidant activities. The objective of this study was to demonstrate apoptotic effects of Kaempferia parviflora Wall. ex. Baker rhizome ethanolic extract on HL-60 cells in...
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2014
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th-cmuir.6653943832-23292014-08-30T02:00:43Z Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells Banjerdpongchai R. Suwannachot K. Rattanapanone V. Sripanidkulchai B. Kaempferia parviflora Wall. ex. Baker is a Thai herb containing many flavonoids that have anti-inflammatory, anti-allergic and antioxidant activities. The objective of this study was to demonstrate apoptotic effects of Kaempferia parviflora Wall. ex. Baker rhizome ethanolic extract on HL-60 cells in vitro. The extract suppressed HL-60 cell growth and decreased cell viability in a dose- and time-dependent manner. Apoptotic cell death was demonstrated by changes in cell morphology, externalization of phosphatidylserine on the cell surface, loss in mitochondrial transmembrane potential and activation of caspase 3. Apoptosis induced by K. parviflora Wall. ex. Baker rhizome ethanolic extract was enhanced by treatment with paclitaxel or doxorubicin, and inhibitors of Akt, PI3-K and MEK. 2014-08-30T02:00:43Z 2014-08-30T02:00:43Z 2008 Article 15137368 19256745 http://www.scopus.com/inward/record.url?eid=2-s2.0-66149086198&partnerID=40&md5=24f3bd1ab9823ef40ea9c7a90f0a50ae http://www.ncbi.nlm.nih.gov/pubmed/19256745 http://cmuir.cmu.ac.th/handle/6653943832/2329 English |
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Kaempferia parviflora Wall. ex. Baker is a Thai herb containing many flavonoids that have anti-inflammatory, anti-allergic and antioxidant activities. The objective of this study was to demonstrate apoptotic effects of Kaempferia parviflora Wall. ex. Baker rhizome ethanolic extract on HL-60 cells in vitro. The extract suppressed HL-60 cell growth and decreased cell viability in a dose- and time-dependent manner. Apoptotic cell death was demonstrated by changes in cell morphology, externalization of phosphatidylserine on the cell surface, loss in mitochondrial transmembrane potential and activation of caspase 3. Apoptosis induced by K. parviflora Wall. ex. Baker rhizome ethanolic extract was enhanced by treatment with paclitaxel or doxorubicin, and inhibitors of Akt, PI3-K and MEK. |
| format |
Article |
| author |
Banjerdpongchai R. Suwannachot K. Rattanapanone V. Sripanidkulchai B. |
| spellingShingle |
Banjerdpongchai R. Suwannachot K. Rattanapanone V. Sripanidkulchai B. Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells |
| author_facet |
Banjerdpongchai R. Suwannachot K. Rattanapanone V. Sripanidkulchai B. |
| author_sort |
Banjerdpongchai R. |
| title |
Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells |
| title_short |
Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells |
| title_full |
Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells |
| title_fullStr |
Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells |
| title_full_unstemmed |
Ethanolic rhizome extract from Kaempferia parviflora Wall. ex. Baker Induces apoptosis in HL-60 cells |
| title_sort |
ethanolic rhizome extract from kaempferia parviflora wall. ex. baker induces apoptosis in hl-60 cells |
| publishDate |
2014 |
| url |
http://www.scopus.com/inward/record.url?eid=2-s2.0-66149086198&partnerID=40&md5=24f3bd1ab9823ef40ea9c7a90f0a50ae http://www.ncbi.nlm.nih.gov/pubmed/19256745 http://cmuir.cmu.ac.th/handle/6653943832/2329 |
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1681419838214373376 |