Mutation in murine coronavirus replication protein nsp4 alters assembly of double membrane vesicles

• Main Authors: Clementz M.A., Kanjanahaluethai A., O'Brien T.E., Baker S.C.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-42749085841&partnerID=40&md5=54d8d972219ab123b0a47b3ef8b4136a; http://cmuir.cmu.ac.th/handle/6653943832/2429
• Institution: Chiang Mai University

Coronaviruses are positive-strand RNA viruses that replicate in the cytoplasm of infected cells by generating a membrane-associated replicase complex. The replicase complex assembles on double membrane vesicles (DMVs). Here, we studied the role of a putative replicase anchor, nonstructural protein 4...