Increased urinary 1,N6-ethenodeoxyadenosine and 3,N4-ethenodeoxycytidine excretion in thalassemia patients: Markers for lipid peroxidation-induced DNA damage

• المؤلفون الرئيسيون: Meerang M., Nair J., Sirankapracha P., Thephinlap C., Srichairatanakool S., Fucharoen S., Bartsch H.
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الوصول للمادة أونلاين: http://www.scopus.com/inward/record.url?eid=2-s2.0-42649091793&partnerID=40&md5=1d5ebfd596c6d0f8e558a252823d5855; http://cmuir.cmu.ac.th/handle/6653943832/2430
• المؤسسة: Chiang Mai University

Thalassemic diseases including homozygous β-thalassemia and β-thalassemia/Hb E (β-Thal/Hb E) are prevalent in Southeast Asia. Iron overload is a common complication in β-thalassemia patients which induces intracellular oxidative stress and lipid peroxidation (LPO). LPO end products generate miscodin...