Steroid-resistant nephrotic syndrome associated with Kimura's disease

Kimura's disease is a chronic inflammatory disease characterized by tumor-like lesions in the soft tissue and lymph nodes of head and neck area or parotid gland. It has a high frequency of an association with nephrotic syndrome. Reported cases of nephrotic syndrome and Kimura's disease wer...

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Bibliographic Details
Main Authors: Chartapisak W., Opastirakul S.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-0036048599&partnerID=40&md5=112ac68086e066338c9fe0df4b043cc0
http://www.ncbi.nlm.nih.gov/pubmed/12169873
http://cmuir.cmu.ac.th/handle/6653943832/2432
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Institution: Chiang Mai University
Language: English
Description
Summary:Kimura's disease is a chronic inflammatory disease characterized by tumor-like lesions in the soft tissue and lymph nodes of head and neck area or parotid gland. It has a high frequency of an association with nephrotic syndrome. Reported cases of nephrotic syndrome and Kimura's disease were mostly from adult patients with only 5 children mentioned. This study reports the case of a 15-year-old-boy who manifested with steroid-resistant nephrotic syndrome for 4 years. Pathological examination of the kidney revealed mild mesangial proliferation. Subsequently, he developed a soft-tissue mass in the parotid gland area. Histopathological investigation of the mass revealed eosinophilic infiltration together with plasma cells and mast cells which is a main characteristic of Kimura's disease. The patient, however, continued to have nephrotic-range proteinuria after removing the subcutaneous mass. Copyright © 2002 S. Karger AG, Basel.