Fetal cytomegalovirus infection associated with cerebral hemorrhage, hydrops fetalis, and echogenic bowel: Case report

We describe some fetal ultrasound findings associated with intrauterine cytomegalovirus (CMV) infection. We report a 38-year-old gravida 3, para 2 at 16 weeks of gestation who underwent ultrasound examination for anomaly screening. The scan revealed an extensive irregular echogenic area in the fetal...

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Main Authors: Tongsong T., Sukpan K., Wanapirak C., Phadungkiatwattna P.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-42349096071&partnerID=40&md5=ecce059624e772fd82e1e85943677e50
http://www.ncbi.nlm.nih.gov/pubmed/18417974
http://cmuir.cmu.ac.th/handle/6653943832/2490
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-24902014-08-30T02:00:54Z Fetal cytomegalovirus infection associated with cerebral hemorrhage, hydrops fetalis, and echogenic bowel: Case report Tongsong T. Sukpan K. Wanapirak C. Phadungkiatwattna P. We describe some fetal ultrasound findings associated with intrauterine cytomegalovirus (CMV) infection. We report a 38-year-old gravida 3, para 2 at 16 weeks of gestation who underwent ultrasound examination for anomaly screening. The scan revealed an extensive irregular echogenic area in the fetal brain, especially at the level of lateral ventricles, suggestive of intraventricular and cerebral hemorrhage. Cardiomegaly, hepatomegaly, and mild ascites as well as an echogenic bowel were demonstrated. Abnormal chromosomes and hemoglobin Bart disease were excluded by analysis of fetal blood. Follow-up ultrasound at 20 weeks of gestation showed frank hydrops fetalis, and termination of the pregnancy was performed based on the couple's decision, giving stillbirth to a male fetus weighing 450 g. Autopsy findings showed intracerebral hemorrhage (right cerebral hemisphere) and hydrops fetalis with hepatosplenomegaly. Microscopic investigation showed typical changes of CMV infection in several organs, including brain, thyroid gland, lung, liver, kidney, heart, pancreas, and placenta. Sonographically, the combination of hydrops fetalis, cerebral hemorrhage, and hyperechoic bowel should raise the possibility of a CMV infection, particularly in cases with no obvious cause of hydrops fetalis. Copyright © 2008 S. Karger AG. 2014-08-30T02:00:54Z 2014-08-30T02:00:54Z 2008 Article 10153837 10.1159/000116737 18417974 FDTHE http://www.scopus.com/inward/record.url?eid=2-s2.0-42349096071&partnerID=40&md5=ecce059624e772fd82e1e85943677e50 http://www.ncbi.nlm.nih.gov/pubmed/18417974 http://cmuir.cmu.ac.th/handle/6653943832/2490 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description We describe some fetal ultrasound findings associated with intrauterine cytomegalovirus (CMV) infection. We report a 38-year-old gravida 3, para 2 at 16 weeks of gestation who underwent ultrasound examination for anomaly screening. The scan revealed an extensive irregular echogenic area in the fetal brain, especially at the level of lateral ventricles, suggestive of intraventricular and cerebral hemorrhage. Cardiomegaly, hepatomegaly, and mild ascites as well as an echogenic bowel were demonstrated. Abnormal chromosomes and hemoglobin Bart disease were excluded by analysis of fetal blood. Follow-up ultrasound at 20 weeks of gestation showed frank hydrops fetalis, and termination of the pregnancy was performed based on the couple's decision, giving stillbirth to a male fetus weighing 450 g. Autopsy findings showed intracerebral hemorrhage (right cerebral hemisphere) and hydrops fetalis with hepatosplenomegaly. Microscopic investigation showed typical changes of CMV infection in several organs, including brain, thyroid gland, lung, liver, kidney, heart, pancreas, and placenta. Sonographically, the combination of hydrops fetalis, cerebral hemorrhage, and hyperechoic bowel should raise the possibility of a CMV infection, particularly in cases with no obvious cause of hydrops fetalis. Copyright © 2008 S. Karger AG.
format Article
author Tongsong T.
Sukpan K.
Wanapirak C.
Phadungkiatwattna P.
spellingShingle Tongsong T.
Sukpan K.
Wanapirak C.
Phadungkiatwattna P.
Fetal cytomegalovirus infection associated with cerebral hemorrhage, hydrops fetalis, and echogenic bowel: Case report
author_facet Tongsong T.
Sukpan K.
Wanapirak C.
Phadungkiatwattna P.
author_sort Tongsong T.
title Fetal cytomegalovirus infection associated with cerebral hemorrhage, hydrops fetalis, and echogenic bowel: Case report
title_short Fetal cytomegalovirus infection associated with cerebral hemorrhage, hydrops fetalis, and echogenic bowel: Case report
title_full Fetal cytomegalovirus infection associated with cerebral hemorrhage, hydrops fetalis, and echogenic bowel: Case report
title_fullStr Fetal cytomegalovirus infection associated with cerebral hemorrhage, hydrops fetalis, and echogenic bowel: Case report
title_full_unstemmed Fetal cytomegalovirus infection associated with cerebral hemorrhage, hydrops fetalis, and echogenic bowel: Case report
title_sort fetal cytomegalovirus infection associated with cerebral hemorrhage, hydrops fetalis, and echogenic bowel: case report
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-42349096071&partnerID=40&md5=ecce059624e772fd82e1e85943677e50
http://www.ncbi.nlm.nih.gov/pubmed/18417974
http://cmuir.cmu.ac.th/handle/6653943832/2490
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