Plasma urocortin in acute myocardial infarction patients

Background Despite its proposed cardioprotective effect, the role of plasma urocortin in acute myocardial infarction (AMI) remains unknown. We investigated plasma profile of urocortin in AMI patients and evaluated its long-term prognostic performance. Material and methods Sixty-six AMI patients and...

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Main Authors: Phrommintikul A., Sivasinprasasn S., Lailerd N., Chattipakorn S., Kuanprasert S., Chattipakorn N.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-77956534017&partnerID=40&md5=86ff84ec2e0ae202108a59a008400d62
http://www.ncbi.nlm.nih.gov/pubmed/20636379
http://cmuir.cmu.ac.th/handle/6653943832/2540
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-25402014-08-30T02:00:57Z Plasma urocortin in acute myocardial infarction patients Phrommintikul A. Sivasinprasasn S. Lailerd N. Chattipakorn S. Kuanprasert S. Chattipakorn N. Background Despite its proposed cardioprotective effect, the role of plasma urocortin in acute myocardial infarction (AMI) remains unknown. We investigated plasma profile of urocortin in AMI patients and evaluated its long-term prognostic performance. Material and methods Sixty-six AMI patients and 21 healthy subjects were included in this study. Blood samples for urocortin were collected on days 0 (onset), 1, 3 and 5 and at 3 and 6 months. Primary endpoint was mortality within 1 year of follow-up. Secondary endpoint was combined death and nonfatal adverse cardiac events (i.e. myocardial reinfarction, urgent revascularization or hospitalization due to heart failure) within 1 year. Results During follow-up at 1 year, 38 (57·6%) patients were alive without cardiac events, nine (13·6%) had nonfatal cardiac events and 17 (25·8%) died. Plasma urocortin in AMI patients were increased on days 0, 1, 3 and 5 (P < 0·05 vs. control). The receiver-operating characteristic curve showed an area under curve (AUC) of day 0 urocortin to be 0·750 with 95% confidence interval (CI) of 0·619-0·881 (P = 0·004), whereas AUC of NT-proBNP was 0·857 (95% CI, 0·722-0·992; P = 0·003). Sensitivity values for predicting the mortality of urocortin NT-proBNP and a combined urocortin and NT-proBNP were 0·81 (95% CI, 0·54-0·95), 0·86 (95% CI, 0·42-0·99) and 1·0 (95% CI, 0·56-1·0), respectively. Conclusions Plasma urocortin level is elevated in AMI patients for 5 days from onset. High plasma urocortin within 24 h after the onset is associated with increased mortality. Combined urocortin and NT-proBNP enhance prognostic performance in AMI patients. © 2010 Stichting European Society for Clinical Investigation Journal Foundation. 2014-08-30T02:00:57Z 2014-08-30T02:00:57Z 2010 Article 142972 10.1111/j.1365-2362.2010.02343.x 20636379 EJCIB http://www.scopus.com/inward/record.url?eid=2-s2.0-77956534017&partnerID=40&md5=86ff84ec2e0ae202108a59a008400d62 http://www.ncbi.nlm.nih.gov/pubmed/20636379 http://cmuir.cmu.ac.th/handle/6653943832/2540 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Background Despite its proposed cardioprotective effect, the role of plasma urocortin in acute myocardial infarction (AMI) remains unknown. We investigated plasma profile of urocortin in AMI patients and evaluated its long-term prognostic performance. Material and methods Sixty-six AMI patients and 21 healthy subjects were included in this study. Blood samples for urocortin were collected on days 0 (onset), 1, 3 and 5 and at 3 and 6 months. Primary endpoint was mortality within 1 year of follow-up. Secondary endpoint was combined death and nonfatal adverse cardiac events (i.e. myocardial reinfarction, urgent revascularization or hospitalization due to heart failure) within 1 year. Results During follow-up at 1 year, 38 (57·6%) patients were alive without cardiac events, nine (13·6%) had nonfatal cardiac events and 17 (25·8%) died. Plasma urocortin in AMI patients were increased on days 0, 1, 3 and 5 (P < 0·05 vs. control). The receiver-operating characteristic curve showed an area under curve (AUC) of day 0 urocortin to be 0·750 with 95% confidence interval (CI) of 0·619-0·881 (P = 0·004), whereas AUC of NT-proBNP was 0·857 (95% CI, 0·722-0·992; P = 0·003). Sensitivity values for predicting the mortality of urocortin NT-proBNP and a combined urocortin and NT-proBNP were 0·81 (95% CI, 0·54-0·95), 0·86 (95% CI, 0·42-0·99) and 1·0 (95% CI, 0·56-1·0), respectively. Conclusions Plasma urocortin level is elevated in AMI patients for 5 days from onset. High plasma urocortin within 24 h after the onset is associated with increased mortality. Combined urocortin and NT-proBNP enhance prognostic performance in AMI patients. © 2010 Stichting European Society for Clinical Investigation Journal Foundation.
format Article
author Phrommintikul A.
Sivasinprasasn S.
Lailerd N.
Chattipakorn S.
Kuanprasert S.
Chattipakorn N.
spellingShingle Phrommintikul A.
Sivasinprasasn S.
Lailerd N.
Chattipakorn S.
Kuanprasert S.
Chattipakorn N.
Plasma urocortin in acute myocardial infarction patients
author_facet Phrommintikul A.
Sivasinprasasn S.
Lailerd N.
Chattipakorn S.
Kuanprasert S.
Chattipakorn N.
author_sort Phrommintikul A.
title Plasma urocortin in acute myocardial infarction patients
title_short Plasma urocortin in acute myocardial infarction patients
title_full Plasma urocortin in acute myocardial infarction patients
title_fullStr Plasma urocortin in acute myocardial infarction patients
title_full_unstemmed Plasma urocortin in acute myocardial infarction patients
title_sort plasma urocortin in acute myocardial infarction patients
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-77956534017&partnerID=40&md5=86ff84ec2e0ae202108a59a008400d62
http://www.ncbi.nlm.nih.gov/pubmed/20636379
http://cmuir.cmu.ac.th/handle/6653943832/2540
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