Transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid from Terminalia chebula galls

Objectives: To investigate transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid in the semipurified fraction isolated from Terminalia chebula Retz. (Combretaceae) galls. Materials and methods: Nonelastic and elastic niosomes loaded with gallic acid in pure fo...

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Main Authors: Manosroi A., Jantrawut P., Akazawa H., Akihisa T., Manosroi W., Manosroi J.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-79955829757&partnerID=40&md5=1820bda6515ae88290437da8332a4995
http://www.ncbi.nlm.nih.gov/pubmed/21284426
http://cmuir.cmu.ac.th/handle/6653943832/2651
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-26512014-08-30T02:25:12Z Transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid from Terminalia chebula galls Manosroi A. Jantrawut P. Akazawa H. Akihisa T. Manosroi W. Manosroi J. Objectives: To investigate transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid in the semipurified fraction isolated from Terminalia chebula Retz. (Combretaceae) galls. Materials and methods: Nonelastic and elastic niosomes loaded with gallic acid in pure form or in the semipurified fraction were developed. Rat skin permeation by vertical Franz diffusion cells of gallic acid from various gel formulations containing elastic niosomes loaded with gallic acid or the semipurified fraction was performed. Results: Elastic and nonelastic niosomes loaded with gallic acid or the semipurified fraction exhibited the mixture of unilamellar and multilamellar structures with negative zeta potential values and in the size range of 200-400nm. Both loaded elastic and nonelastic niosomes showed good physical and chemical stability for 3 months. The percentages remaining of gallic acid in nonelastic were slightly higher than in elastic niosomes. Both elastic and nonelastic niosomes retarded rat skin permeation of the loaded pure gallic acid, while enhanced the loaded gallic acid in the semipurified fraction. However, elastic niosomes exhibited higher percentages of gallic acid through rat skin than the nonelastic niosomes. Discussion and conclusion: This study has demonstrated the potential of niosomes, especially elastic niosomes, for the enhancement of chemical stability and rat skin transdermal absorption of gallic acid in the semipurified fraction from T. chebula galls, which will be beneficial for topical antiaging application. © 2011 Informa Healthcare USA, Inc. 2014-08-30T02:25:12Z 2014-08-30T02:25:12Z 2011 Article 13880209 10.3109/13880209.2010.528432 21284426 PHBIF http://www.scopus.com/inward/record.url?eid=2-s2.0-79955829757&partnerID=40&md5=1820bda6515ae88290437da8332a4995 http://www.ncbi.nlm.nih.gov/pubmed/21284426 http://cmuir.cmu.ac.th/handle/6653943832/2651 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Objectives: To investigate transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid in the semipurified fraction isolated from Terminalia chebula Retz. (Combretaceae) galls. Materials and methods: Nonelastic and elastic niosomes loaded with gallic acid in pure form or in the semipurified fraction were developed. Rat skin permeation by vertical Franz diffusion cells of gallic acid from various gel formulations containing elastic niosomes loaded with gallic acid or the semipurified fraction was performed. Results: Elastic and nonelastic niosomes loaded with gallic acid or the semipurified fraction exhibited the mixture of unilamellar and multilamellar structures with negative zeta potential values and in the size range of 200-400nm. Both loaded elastic and nonelastic niosomes showed good physical and chemical stability for 3 months. The percentages remaining of gallic acid in nonelastic were slightly higher than in elastic niosomes. Both elastic and nonelastic niosomes retarded rat skin permeation of the loaded pure gallic acid, while enhanced the loaded gallic acid in the semipurified fraction. However, elastic niosomes exhibited higher percentages of gallic acid through rat skin than the nonelastic niosomes. Discussion and conclusion: This study has demonstrated the potential of niosomes, especially elastic niosomes, for the enhancement of chemical stability and rat skin transdermal absorption of gallic acid in the semipurified fraction from T. chebula galls, which will be beneficial for topical antiaging application. © 2011 Informa Healthcare USA, Inc.
format Article
author Manosroi A.
Jantrawut P.
Akazawa H.
Akihisa T.
Manosroi W.
Manosroi J.
spellingShingle Manosroi A.
Jantrawut P.
Akazawa H.
Akihisa T.
Manosroi W.
Manosroi J.
Transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid from Terminalia chebula galls
author_facet Manosroi A.
Jantrawut P.
Akazawa H.
Akihisa T.
Manosroi W.
Manosroi J.
author_sort Manosroi A.
title Transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid from Terminalia chebula galls
title_short Transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid from Terminalia chebula galls
title_full Transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid from Terminalia chebula galls
title_fullStr Transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid from Terminalia chebula galls
title_full_unstemmed Transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid from Terminalia chebula galls
title_sort transdermal absorption enhancement of gel containing elastic niosomes loaded with gallic acid from terminalia chebula galls
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-79955829757&partnerID=40&md5=1820bda6515ae88290437da8332a4995
http://www.ncbi.nlm.nih.gov/pubmed/21284426
http://cmuir.cmu.ac.th/handle/6653943832/2651
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