Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients

Background: A simple, convenient, and accurate method for detecting urine protein excretion in lupus nephritis is crucial. Objectives: The objectives of the study were to determine the sensitivity and the specificity of the qualitative urine dipstick test value to detect 0.50 g or greater of the qua...

Full description

Saved in:
Bibliographic Details
Main Authors: Chotayaporn T., Kasitanon N., Sukitawut W., Louthrenoo W.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-79955072719&partnerID=40&md5=27b9deb50f1df93e0333943e68742998
http://www.ncbi.nlm.nih.gov/pubmed/21441821
http://cmuir.cmu.ac.th/handle/6653943832/2677
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
Language: English
id th-cmuir.6653943832-2677
record_format dspace
spelling th-cmuir.6653943832-26772014-08-30T02:25:15Z Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients Chotayaporn T. Kasitanon N. Sukitawut W. Louthrenoo W. Background: A simple, convenient, and accurate method for detecting urine protein excretion in lupus nephritis is crucial. Objectives: The objectives of the study were to determine the sensitivity and the specificity of the qualitative urine dipstick test value to detect 0.50 g or greater of the quantitative 24-hour urine protein (24-hUP) in lupus patients, to evaluate an overall agreement of the dipstick test results and the magnitude of 24-hUP, and to examine the correlation between the spot urine protein creatinine index (S-UPCI) and the 24-hour UPCI with that of the 24-hUp. Methods: A prospective study was conducted in 92 patients with lupus. All dipstick test values from 5 dipstick assays (Bayer, Roche, Meditest USA, Standard Diagnostics, and Arkray) and the S-UPCI were obtained within 6 hours of the 24-hUP collection. Of 149 urine samples, only 39% were collected properly and were used for analysis. Results: The sensitivity and specificity of a ≥2+ dipstick test result to detect 0.50 g or greater 24-hUP were 56-% to 80% and 67% to 92%, respectively. The agreement of the urine dipstick test values and the magnitude of 24-hUP was fair (κ = 0.23-0.32). The correlation between the S-UPCI and the 24-hUP was 0.83 (P < 0.0001), and that of the 24-hour UPCI and the 24-hUP was 1 (P < 0.0001). Using 24-hUP 2 g/d or less, the bias ±1.96 SD of the difference of S-UPCI and 24-hUP was 0.23 (SD, 0.96) g. Conclusions: A ≥2+ dipstick test is relatively sensitive to detect significant proteinuria, but it is poorly correlated with quantitative 24-hUP. The S-UPCI and the 24-hUP can be used interchangeably for follow-up in lupus nephritis patients with proteinuria of less than 2 g/d. Copyright © 2011 Lippincott Williams & Wilkins. 2014-08-30T02:25:15Z 2014-08-30T02:25:15Z 2011 Article 10761608 10.1097/RHU.0b013e318214bd18 21441821 JCRHF http://www.scopus.com/inward/record.url?eid=2-s2.0-79955072719&partnerID=40&md5=27b9deb50f1df93e0333943e68742998 http://www.ncbi.nlm.nih.gov/pubmed/21441821 http://cmuir.cmu.ac.th/handle/6653943832/2677 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Background: A simple, convenient, and accurate method for detecting urine protein excretion in lupus nephritis is crucial. Objectives: The objectives of the study were to determine the sensitivity and the specificity of the qualitative urine dipstick test value to detect 0.50 g or greater of the quantitative 24-hour urine protein (24-hUP) in lupus patients, to evaluate an overall agreement of the dipstick test results and the magnitude of 24-hUP, and to examine the correlation between the spot urine protein creatinine index (S-UPCI) and the 24-hour UPCI with that of the 24-hUp. Methods: A prospective study was conducted in 92 patients with lupus. All dipstick test values from 5 dipstick assays (Bayer, Roche, Meditest USA, Standard Diagnostics, and Arkray) and the S-UPCI were obtained within 6 hours of the 24-hUP collection. Of 149 urine samples, only 39% were collected properly and were used for analysis. Results: The sensitivity and specificity of a ≥2+ dipstick test result to detect 0.50 g or greater 24-hUP were 56-% to 80% and 67% to 92%, respectively. The agreement of the urine dipstick test values and the magnitude of 24-hUP was fair (κ = 0.23-0.32). The correlation between the S-UPCI and the 24-hUP was 0.83 (P < 0.0001), and that of the 24-hour UPCI and the 24-hUP was 1 (P < 0.0001). Using 24-hUP 2 g/d or less, the bias ±1.96 SD of the difference of S-UPCI and 24-hUP was 0.23 (SD, 0.96) g. Conclusions: A ≥2+ dipstick test is relatively sensitive to detect significant proteinuria, but it is poorly correlated with quantitative 24-hUP. The S-UPCI and the 24-hUP can be used interchangeably for follow-up in lupus nephritis patients with proteinuria of less than 2 g/d. Copyright © 2011 Lippincott Williams & Wilkins.
format Article
author Chotayaporn T.
Kasitanon N.
Sukitawut W.
Louthrenoo W.
spellingShingle Chotayaporn T.
Kasitanon N.
Sukitawut W.
Louthrenoo W.
Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients
author_facet Chotayaporn T.
Kasitanon N.
Sukitawut W.
Louthrenoo W.
author_sort Chotayaporn T.
title Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients
title_short Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients
title_full Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients
title_fullStr Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients
title_full_unstemmed Comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients
title_sort comparison of proteinuria determination by urine dipstick, spot urine protein creatinine index, and urine protein 24 hours in lupus patients
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-79955072719&partnerID=40&md5=27b9deb50f1df93e0333943e68742998
http://www.ncbi.nlm.nih.gov/pubmed/21441821
http://cmuir.cmu.ac.th/handle/6653943832/2677
_version_ 1681419903964282880