Impact of incomplete plan to treatment results of concurrent weekly cisplatin and radiotherapy in locally advanced cervical cancer

To evaluate the efficacy of incomplete treatment protocols of cisplatin in concurrent chemoradiation for locally advanced cervical carcinoma. This retrospective study was performed in 165 consecutively treated patients with locally advanced cervical cancer who received a weekly cisplatin regimen. Th...

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Main Authors: Tharavichitkul E., Pinitpatcharalerd A., Lorvidhaya V., Kamnerdsupaphon P., Pukanhaphan N., Sukthomya V., Chitapanarax I., Galalae R.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-79751481689&partnerID=40&md5=9e290b0b27bd049ef315a19a0caff42b
http://www.ncbi.nlm.nih.gov/pubmed/21187669
http://cmuir.cmu.ac.th/handle/6653943832/2703
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-27032014-08-30T02:25:17Z Impact of incomplete plan to treatment results of concurrent weekly cisplatin and radiotherapy in locally advanced cervical cancer Tharavichitkul E. Pinitpatcharalerd A. Lorvidhaya V. Kamnerdsupaphon P. Pukanhaphan N. Sukthomya V. Chitapanarax I. Galalae R. To evaluate the efficacy of incomplete treatment protocols of cisplatin in concurrent chemoradiation for locally advanced cervical carcinoma. This retrospective study was performed in 165 consecutively treated patients with locally advanced cervical cancer who received a weekly cisplatin regimen. The number of weekly cisplatin cycles of each patient was recorded and used to discriminate between patients. Local control, disease free survival, distant metastasis-free survival, and toxicities were calculated using the software package SPSS version 15.0. Ninety-two patients (55%) completed the planned protocol of six cycles of weekly cisplatin. With the median follow-up time of 38.2 months, the 3-year local control rate differed significantly in the two patient groups (95.4% of 6 cycles versus 84.8% of < 6 cycles; p = 0.028). No statistical significance was observed for disease-free survival (74.6% versus 74.5%; p = 0.22) and distant metastasis-free survival (76.5% vs. 75.7%; p = 0.88). In conclusion, the plan completion of concurrent cisplatin with radiotherapy was responsible for better local control. However, differences in disease-free survival and distant metastasis-free survival were not statistical significant. 2014-08-30T02:25:17Z 2014-08-30T02:25:17Z 2011 Article 4493060 10.1269/jrr.10021 21187669 http://www.scopus.com/inward/record.url?eid=2-s2.0-79751481689&partnerID=40&md5=9e290b0b27bd049ef315a19a0caff42b http://www.ncbi.nlm.nih.gov/pubmed/21187669 http://cmuir.cmu.ac.th/handle/6653943832/2703 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description To evaluate the efficacy of incomplete treatment protocols of cisplatin in concurrent chemoradiation for locally advanced cervical carcinoma. This retrospective study was performed in 165 consecutively treated patients with locally advanced cervical cancer who received a weekly cisplatin regimen. The number of weekly cisplatin cycles of each patient was recorded and used to discriminate between patients. Local control, disease free survival, distant metastasis-free survival, and toxicities were calculated using the software package SPSS version 15.0. Ninety-two patients (55%) completed the planned protocol of six cycles of weekly cisplatin. With the median follow-up time of 38.2 months, the 3-year local control rate differed significantly in the two patient groups (95.4% of 6 cycles versus 84.8% of < 6 cycles; p = 0.028). No statistical significance was observed for disease-free survival (74.6% versus 74.5%; p = 0.22) and distant metastasis-free survival (76.5% vs. 75.7%; p = 0.88). In conclusion, the plan completion of concurrent cisplatin with radiotherapy was responsible for better local control. However, differences in disease-free survival and distant metastasis-free survival were not statistical significant.
format Article
author Tharavichitkul E.
Pinitpatcharalerd A.
Lorvidhaya V.
Kamnerdsupaphon P.
Pukanhaphan N.
Sukthomya V.
Chitapanarax I.
Galalae R.
spellingShingle Tharavichitkul E.
Pinitpatcharalerd A.
Lorvidhaya V.
Kamnerdsupaphon P.
Pukanhaphan N.
Sukthomya V.
Chitapanarax I.
Galalae R.
Impact of incomplete plan to treatment results of concurrent weekly cisplatin and radiotherapy in locally advanced cervical cancer
author_facet Tharavichitkul E.
Pinitpatcharalerd A.
Lorvidhaya V.
Kamnerdsupaphon P.
Pukanhaphan N.
Sukthomya V.
Chitapanarax I.
Galalae R.
author_sort Tharavichitkul E.
title Impact of incomplete plan to treatment results of concurrent weekly cisplatin and radiotherapy in locally advanced cervical cancer
title_short Impact of incomplete plan to treatment results of concurrent weekly cisplatin and radiotherapy in locally advanced cervical cancer
title_full Impact of incomplete plan to treatment results of concurrent weekly cisplatin and radiotherapy in locally advanced cervical cancer
title_fullStr Impact of incomplete plan to treatment results of concurrent weekly cisplatin and radiotherapy in locally advanced cervical cancer
title_full_unstemmed Impact of incomplete plan to treatment results of concurrent weekly cisplatin and radiotherapy in locally advanced cervical cancer
title_sort impact of incomplete plan to treatment results of concurrent weekly cisplatin and radiotherapy in locally advanced cervical cancer
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-79751481689&partnerID=40&md5=9e290b0b27bd049ef315a19a0caff42b
http://www.ncbi.nlm.nih.gov/pubmed/21187669
http://cmuir.cmu.ac.th/handle/6653943832/2703
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