Intraocular and plasma HIV-1 RNA loads and HIV uveitis

• Main Authors: Pathanapitoon K., Riemens A., Kongyai N., Sirirungsi W., Leechanachai P., Ausayakhun S., Ayuso V.K., Kunavisarut P., De Groot-Mijnes J.D., Rothova A.
• 格式: Article
• 語言: English
• 出版: 2014
• 在線閱讀: http://www.scopus.com/inward/record.url?eid=2-s2.0-78650303556&partnerID=40&md5=e523cba018b7d649fcb8a46a4f16254b; http://www.ncbi.nlm.nih.gov/pubmed/21099669; http://cmuir.cmu.ac.th/handle/6653943832/2719

Objective: The objective of this study was to analyze human immunodeficiency virus (HIV) dynamics across the blood-retinal barrier and to determine whether the high levels of HIV in the eye are associated with any ocular disorders in HIV-infected patients. Design: This study included a prospective case series of 40 HIV-positive patients with uveitis. INTERVENTION:: Clinical and laboratory examinations included plasma and intraocular HIV-1 RNA loads as well as the clinical manifestations of uveitis. Results: Intraocular HIV-1 RNA was detected in 32% (13/40) of HIV-positive patients with uveitis. Intraocular HIV-1 RNA loads were associated with high HIV-1 RNA plasma loads (P < 0.001) and not being on HAART therapy (P = 0.005). In addition, detectable intraocular HIV-1 RNA levels were higher in patients with the absence of retinal lesions (P = 0.008). In three patients, the HIV load in the eye largely exceeded that of plasma. These three patients had all bilateral anterior uveitis and/or vitritis without retinal lesions and exhibited no evidence of other intraocular infectious agents causing uveitis than HIV itself. Conclusion: The eye can form a sanctuary where HIV might replicate and cause an inflammatory reaction. © 2011 Wolters Kluwer Health | Lippincott Williams & Wilkins.