In vitro suppression of the MMP-3 gene in normal and cytokine-treated human chondrosarcoma using small interfering RNA

• Main Authors: Nganvongpanit K., Chaochird P., Siengdee P., Pothacharoen P., Klunklin K., Chomdej S., Mekchay S., Kongtaweelert P.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-77953665391&partnerID=40&md5=44960cf99bdaa0d4ea0c784398f83da6; http://www.ncbi.nlm.nih.gov/pubmed/20034400; http://cmuir.cmu.ac.th/handle/6653943832/2730
• Institution: Chiang Mai University

Background: Matrix metalloproteinase (MMPs) synthesized and secreted from connective tissue cells have been thought to participate in degradation of the extracellular matrix. Increased MMPs activities that degrade proteoglycans have been measured in osteoarthritis cartilage. This study aims to suppr...