Evolutionary consequences of G9 rotaviruses circulating in Thailand

Infection with group A rotaviruses is the main cause of acute gastroenteritis in infants and young children worldwide. Rotavirus G9 is recognized as the fifth most predominant G genotype that spreads throughout the world. In this study, we describe the changing distribution of rotavirus G9 genotype...

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Main Authors: Khamrin P., Thongprachum A., Chaimongkol N., Chusri P., Okitsu S., Ushijima H., Maneekarn N.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-70449556880&partnerID=40&md5=ba9fc2c1402ceb2633586c5809b9204f
http://cmuir.cmu.ac.th/handle/6653943832/2746
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-27462014-08-30T02:25:20Z Evolutionary consequences of G9 rotaviruses circulating in Thailand Khamrin P. Thongprachum A. Chaimongkol N. Chusri P. Okitsu S. Ushijima H. Maneekarn N. Infection with group A rotaviruses is the main cause of acute gastroenteritis in infants and young children worldwide. Rotavirus G9 is recognized as the fifth most predominant G genotype that spreads throughout the world. In this study, we describe the changing distribution of rotavirus G9 genotype in Chiang Mai, Thailand, from 1989 to 2005. Molecular genetic evolutionary analysis of the G9 rotavirus VP7 gene was performed. The G9 rotavirus in Thailand was first detected in Chiang Mai in 1989 with a low prevalence of 1.98%, but in 2000 and 2001 it had become the most predominant genotype, reaching prevalence of 75% and 92.2%, respectively. Then, the prevalence of G9 reached a peak of 100% in 2002 and decreased abruptly over the next 3 years, i.e. 16.7% in 2003, 32.1% in 2004, and 4.7% in 2005. Our phylogenetic analysis demonstrates that all the G9 rotaviruses circulating in Thailand belonged to lineage III, and clustered closely together based on the year of virus isolation. One amino acid change from Thr to Ile was observed in antigenic region C at position 208 between the G9 strains isolated in 1989 and the strains of 1997-2005. These findings provide the overall picture and genomic data of G9 rotaviruses circulating in Chiang Mai, Thailand. © 2009 Elsevier B.V. All rights reserved. 2014-08-30T02:25:20Z 2014-08-30T02:25:20Z 2009 Article 15671348 10.1016/j.meegid.2009.08.006 19716437 IGENC http://www.scopus.com/inward/record.url?eid=2-s2.0-70449556880&partnerID=40&md5=ba9fc2c1402ceb2633586c5809b9204f http://cmuir.cmu.ac.th/handle/6653943832/2746 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Infection with group A rotaviruses is the main cause of acute gastroenteritis in infants and young children worldwide. Rotavirus G9 is recognized as the fifth most predominant G genotype that spreads throughout the world. In this study, we describe the changing distribution of rotavirus G9 genotype in Chiang Mai, Thailand, from 1989 to 2005. Molecular genetic evolutionary analysis of the G9 rotavirus VP7 gene was performed. The G9 rotavirus in Thailand was first detected in Chiang Mai in 1989 with a low prevalence of 1.98%, but in 2000 and 2001 it had become the most predominant genotype, reaching prevalence of 75% and 92.2%, respectively. Then, the prevalence of G9 reached a peak of 100% in 2002 and decreased abruptly over the next 3 years, i.e. 16.7% in 2003, 32.1% in 2004, and 4.7% in 2005. Our phylogenetic analysis demonstrates that all the G9 rotaviruses circulating in Thailand belonged to lineage III, and clustered closely together based on the year of virus isolation. One amino acid change from Thr to Ile was observed in antigenic region C at position 208 between the G9 strains isolated in 1989 and the strains of 1997-2005. These findings provide the overall picture and genomic data of G9 rotaviruses circulating in Chiang Mai, Thailand. © 2009 Elsevier B.V. All rights reserved.
format Article
author Khamrin P.
Thongprachum A.
Chaimongkol N.
Chusri P.
Okitsu S.
Ushijima H.
Maneekarn N.
spellingShingle Khamrin P.
Thongprachum A.
Chaimongkol N.
Chusri P.
Okitsu S.
Ushijima H.
Maneekarn N.
Evolutionary consequences of G9 rotaviruses circulating in Thailand
author_facet Khamrin P.
Thongprachum A.
Chaimongkol N.
Chusri P.
Okitsu S.
Ushijima H.
Maneekarn N.
author_sort Khamrin P.
title Evolutionary consequences of G9 rotaviruses circulating in Thailand
title_short Evolutionary consequences of G9 rotaviruses circulating in Thailand
title_full Evolutionary consequences of G9 rotaviruses circulating in Thailand
title_fullStr Evolutionary consequences of G9 rotaviruses circulating in Thailand
title_full_unstemmed Evolutionary consequences of G9 rotaviruses circulating in Thailand
title_sort evolutionary consequences of g9 rotaviruses circulating in thailand
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-70449556880&partnerID=40&md5=ba9fc2c1402ceb2633586c5809b9204f
http://cmuir.cmu.ac.th/handle/6653943832/2746
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