Potency of extemporaneous gentamicin eye drops used in maharaj nakorn chiang mai hospital

• Main Authors: Khangtragool A., Khantawa B., Leesawat P.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-77953805162&partnerID=40&md5=0f0f4003f1b1a1f4a6ce3b9505e95162; http://cmuir.cmu.ac.th/handle/6653943832/2829
• Institution: Chiang Mai University

This study evaluated the potency of extemporaneous gentamicin (13.6 mg/ml) eye drops, stored for 4 weeks. The effects of different storage temperatures on the antimibrobial potency were examined. Gentamicin (13.6 mg/ml) was prepared with aseptic technique and the solutions stored at 2-8°C and 28°C for 28 days. The fortified stock solutions of gentamicin (13.6 mg/ml) were prepared by reconstituting gentamicin (0.3%) eye drops with gentamicin (40 mg/ml) injection. The potency was evaluated by measuring the minimum inhibitory concentration. Throughout the 28-day period, no change was observed in the minimum inhibitory concentration of gentamicin (13.6 mg/ml) stored at 2-8°C and 28°C. Extemporaneously - prepared gentamicin (13.6 mg/ml) eye drops remained stable at 2-8°C and 28°C for 28 days.