Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma

Aim: This study was designed to evaluate the clinical application of serum total sialic acid (ISA) in the diagnosis of cholangiocarcinoma (CCA). Methods: Serum TSA was determined by periodateresorcinol microassay in 69 patients with CCA, 59 patients with hepatocellular carcinoma (HCC), 37 patients w...

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Main Authors: Kongtawelert P., Tangkijvanich P., Ong-Chai S., Poovorawan Y.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-0142183162&partnerID=40&md5=ece5495d72380d50e7d1d92fc79e6dda
http://www.ncbi.nlm.nih.gov/pubmed/14562373
http://cmuir.cmu.ac.th/handle/6653943832/2838
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-28382014-08-30T02:25:27Z Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma Kongtawelert P. Tangkijvanich P. Ong-Chai S. Poovorawan Y. Aim: This study was designed to evaluate the clinical application of serum total sialic acid (ISA) in the diagnosis of cholangiocarcinoma (CCA). Methods: Serum TSA was determined by periodateresorcinol microassay in 69 patients with CCA, 59 patients with hepatocellular carcinoma (HCC), 37 patients with cirrhosis, 61 patients with chronic hepatitis and 50 healthy blood donors. Results: The mean serum TSA concentration in CCA (2.41±0.70 mmol/L) was significantly higher than those of HCC, cirrhosis, chronic hepatitis and healthy blood donors (1.41±0.37 mmol/L, 1.13±0.31 mmol/L, 1.16±0.26 mmol/L, and 1.10±0.14 mmol/L, respectively; p<0.001). Based on ROC curve analysis, a cut-off point of 1.75 mmol/L discriminated between CCA and HCC with a sensitivity, specificity and accuracy of 82.6 %, 83.1 %, and 82.8 %, respectively. Conclusion: Based on our results, serum TSA would be a useful marker for the differential diagnosis of CCA from HCC. 2014-08-30T02:25:27Z 2014-08-30T02:25:27Z 2003 Article 10079327 14562373 WJGAF http://www.scopus.com/inward/record.url?eid=2-s2.0-0142183162&partnerID=40&md5=ece5495d72380d50e7d1d92fc79e6dda http://www.ncbi.nlm.nih.gov/pubmed/14562373 http://cmuir.cmu.ac.th/handle/6653943832/2838 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Aim: This study was designed to evaluate the clinical application of serum total sialic acid (ISA) in the diagnosis of cholangiocarcinoma (CCA). Methods: Serum TSA was determined by periodateresorcinol microassay in 69 patients with CCA, 59 patients with hepatocellular carcinoma (HCC), 37 patients with cirrhosis, 61 patients with chronic hepatitis and 50 healthy blood donors. Results: The mean serum TSA concentration in CCA (2.41±0.70 mmol/L) was significantly higher than those of HCC, cirrhosis, chronic hepatitis and healthy blood donors (1.41±0.37 mmol/L, 1.13±0.31 mmol/L, 1.16±0.26 mmol/L, and 1.10±0.14 mmol/L, respectively; p<0.001). Based on ROC curve analysis, a cut-off point of 1.75 mmol/L discriminated between CCA and HCC with a sensitivity, specificity and accuracy of 82.6 %, 83.1 %, and 82.8 %, respectively. Conclusion: Based on our results, serum TSA would be a useful marker for the differential diagnosis of CCA from HCC.
format Article
author Kongtawelert P.
Tangkijvanich P.
Ong-Chai S.
Poovorawan Y.
spellingShingle Kongtawelert P.
Tangkijvanich P.
Ong-Chai S.
Poovorawan Y.
Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma
author_facet Kongtawelert P.
Tangkijvanich P.
Ong-Chai S.
Poovorawan Y.
author_sort Kongtawelert P.
title Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma
title_short Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma
title_full Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma
title_fullStr Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma
title_full_unstemmed Role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma
title_sort role of serum total sialic acid in differentiating cholangiocarcinoma from hepatocellular carcinoma
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-0142183162&partnerID=40&md5=ece5495d72380d50e7d1d92fc79e6dda
http://www.ncbi.nlm.nih.gov/pubmed/14562373
http://cmuir.cmu.ac.th/handle/6653943832/2838
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