Outcomes of pregnancies affected by hemoglobin H disease

• Main Authors: Tongsong T., Srisupundit K., Luewan S.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-66549098282&partnerID=40&md5=b26fa6e160f186e81f51e727edd64966; http://www.ncbi.nlm.nih.gov/pubmed/19027901; http://cmuir.cmu.ac.th/handle/6653943832/2888
• Institution: Chiang Mai University

Objective: To determine the outcomes of pregnancies affected by hemoglobin H (HbH) disease. Methods: A retrospective cohort study was conducted with 120 women with singleton pregnancies complicated by HbH disease only. The controls-to-cases ratio was 2:1. Results: Maternal outcomes were similar in the 2 groups. The incidences of fetal growth restriction (relative risk [RR], 2.4; 95% confidence interval [CI], 1.60-3.50), preterm birth (RR, 1.4; 95% CI, 1.03-1.96), and low birth weight (RR, 1.9; 95% CI, 1.46-2.56) were significantly higher in the study than in the control group. The perinatal mortality rate was slightly higher in the study group. Conclusion: In spite of attempts to keep hemoglobin levels sufficiently high (> 7.0 g/dL), pregnancies with HbH disease were significantly associated with increased risks of fetal growth restriction, preterm birth, and low birth weight. © 2008 Elsevier Ireland Ltd. All rights reserved.