A phase II study of oxaliplatin with 5-FU/folinic acid and concomitant radiotherapy as a preoperative treatment in patients with locally advanced rectal cancer

• Main Authors: Chitapanarux I., Chitapanarux T., Tharavichitkul E., Mayurasakorn S., Siriwittayakorn P., Yamada S., Lorvidhaya V.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-83455220049&partnerID=40&md5=538b3076f330acc5e7fc1d8cd7c8f095; http://www.ncbi.nlm.nih.gov/pubmed/22279502; http://cmuir.cmu.ac.th/handle/6653943832/2957
• Institution: Chiang Mai University

Objective: To evaluate the activity and safety of adding oxaliplatin to a standard chemoradiotherapy schema, including 5-fluorouracil (5-FU)/folinic acid (FA), in locally-advanced rectal cancer (LARC). Methods: Two cycles of oxaliplatin 130 mg/m2 plus FA 20 mg/m2 bolus for 5 days and 5-FU 350 mg/m2...