HPV genotyping in neuroendocrine carcinoma of the uterine cervix in northern Thailand

Objective: To determine the distribution of HPV genotypes in cervical neuroendocrine carcinoma (NECA) in northern Thailand, and evaluate the correlation between HPV genotype and clinicopathologic features. Methods: Samples from 111 women treated for cervical NECA at Chiang Mai University Hospital be...

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Main Authors: Siriaunkgul S., Utaipat U., Settakorn J., Sukpan K., Srisomboon J., Khunamornpong S.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-80053285589&partnerID=40&md5=35c75e791804cda11a30409355064859
http://www.ncbi.nlm.nih.gov/pubmed/21872245
http://cmuir.cmu.ac.th/handle/6653943832/2977
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-29772014-08-30T02:25:37Z HPV genotyping in neuroendocrine carcinoma of the uterine cervix in northern Thailand Siriaunkgul S. Utaipat U. Settakorn J. Sukpan K. Srisomboon J. Khunamornpong S. Objective: To determine the distribution of HPV genotypes in cervical neuroendocrine carcinoma (NECA) in northern Thailand, and evaluate the correlation between HPV genotype and clinicopathologic features. Methods: Samples from 111 women treated for cervical NECA at Chiang Mai University Hospital between 1992 and 2009 were tested for HPV genotype. Samples were formaldehyde-fixed, paraffin-embedded, and tested via nested PCR and dot blot hybridization. Results: Ninety-seven of the 111 samples were adequate for DNA analysis. HPV DNA was detected in 93 samples, of which 76 (81.7%) were single, 14 (15.1%) were multiple, and 3 (3.2%) were untyped infections. HPV18 was the most common subtype (70 cases, 75.3%), followed by HPV16 (28 cases, 30.1%). Other genotypes included HPV58 (3.2%), HPV52 (2.1%), and HPV33 (1.1%). Collectively, HPV16 and/or HPV18 were found in 83 cases (89.3%). Women with HPV18 infection were significantly younger (42.0 years) than those with non-HPV18 infections (54.1 years) (P = 0.003). Associated adenocarcinoma in situ was more frequently seen among women with HPV18 infection (P = 0.034). Conclusions: HPV18 infection was predominant in cervical NECA. Variations in HPV genotype may be related to the clinicopathologic features and pathogenetic pathways of NECA. Vaccination against HPV16 and HPV18 might provide protection against cervical NECA in almost 90% of cases. © 2011 International Federation of Gynecology and Obstetrics. 2014-08-30T02:25:37Z 2014-08-30T02:25:37Z 2011 Article 207292 10.1016/j.ijgo.2011.06.010 IJGOA http://www.scopus.com/inward/record.url?eid=2-s2.0-80053285589&partnerID=40&md5=35c75e791804cda11a30409355064859 http://www.ncbi.nlm.nih.gov/pubmed/21872245 http://cmuir.cmu.ac.th/handle/6653943832/2977 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Objective: To determine the distribution of HPV genotypes in cervical neuroendocrine carcinoma (NECA) in northern Thailand, and evaluate the correlation between HPV genotype and clinicopathologic features. Methods: Samples from 111 women treated for cervical NECA at Chiang Mai University Hospital between 1992 and 2009 were tested for HPV genotype. Samples were formaldehyde-fixed, paraffin-embedded, and tested via nested PCR and dot blot hybridization. Results: Ninety-seven of the 111 samples were adequate for DNA analysis. HPV DNA was detected in 93 samples, of which 76 (81.7%) were single, 14 (15.1%) were multiple, and 3 (3.2%) were untyped infections. HPV18 was the most common subtype (70 cases, 75.3%), followed by HPV16 (28 cases, 30.1%). Other genotypes included HPV58 (3.2%), HPV52 (2.1%), and HPV33 (1.1%). Collectively, HPV16 and/or HPV18 were found in 83 cases (89.3%). Women with HPV18 infection were significantly younger (42.0 years) than those with non-HPV18 infections (54.1 years) (P = 0.003). Associated adenocarcinoma in situ was more frequently seen among women with HPV18 infection (P = 0.034). Conclusions: HPV18 infection was predominant in cervical NECA. Variations in HPV genotype may be related to the clinicopathologic features and pathogenetic pathways of NECA. Vaccination against HPV16 and HPV18 might provide protection against cervical NECA in almost 90% of cases. © 2011 International Federation of Gynecology and Obstetrics.
format Article
author Siriaunkgul S.
Utaipat U.
Settakorn J.
Sukpan K.
Srisomboon J.
Khunamornpong S.
spellingShingle Siriaunkgul S.
Utaipat U.
Settakorn J.
Sukpan K.
Srisomboon J.
Khunamornpong S.
HPV genotyping in neuroendocrine carcinoma of the uterine cervix in northern Thailand
author_facet Siriaunkgul S.
Utaipat U.
Settakorn J.
Sukpan K.
Srisomboon J.
Khunamornpong S.
author_sort Siriaunkgul S.
title HPV genotyping in neuroendocrine carcinoma of the uterine cervix in northern Thailand
title_short HPV genotyping in neuroendocrine carcinoma of the uterine cervix in northern Thailand
title_full HPV genotyping in neuroendocrine carcinoma of the uterine cervix in northern Thailand
title_fullStr HPV genotyping in neuroendocrine carcinoma of the uterine cervix in northern Thailand
title_full_unstemmed HPV genotyping in neuroendocrine carcinoma of the uterine cervix in northern Thailand
title_sort hpv genotyping in neuroendocrine carcinoma of the uterine cervix in northern thailand
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-80053285589&partnerID=40&md5=35c75e791804cda11a30409355064859
http://www.ncbi.nlm.nih.gov/pubmed/21872245
http://cmuir.cmu.ac.th/handle/6653943832/2977
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