Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients

Purpose: The value of an immunochromatographic test for tuberculosis (ICT-TB) combined with clinical predictors has yet to be evaluated in Thailand. This study aimed to assess any additional diagnostic value of an ICT-TB test over that of clinical predictors in a group of human immunodeficiency viru...

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Main Authors: Nanta S., Kantipong P., Pathipvanich P., Ruengorn C., Tawichasri C., Patumanond J.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-80955160045&partnerID=40&md5=6901f5888a6840284a94555b093b326d
http://www.ncbi.nlm.nih.gov/pubmed/22003307
http://cmuir.cmu.ac.th/handle/6653943832/2999
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spelling th-cmuir.6653943832-29992014-08-30T02:25:38Z Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients Nanta S. Kantipong P. Pathipvanich P. Ruengorn C. Tawichasri C. Patumanond J. Purpose: The value of an immunochromatographic test for tuberculosis (ICT-TB) combined with clinical predictors has yet to be evaluated in Thailand. This study aimed to assess any additional diagnostic value of an ICT-TB test over that of clinical predictors in a group of human immunodeficiency virus (HIV) patients as well as in subgroups of HIV patients classified by clinical risk scores. Patients and methods: An extended cross-sectional study was conducted at a community hospital in Chiang Rai and a general hospital in Lampang. HIV patients registered between April 2009 and May 2010 were screened by a locally made ICT-TB test, including 38, 16, and 6 kD Microbacterium tuberculosis antigens, as well as by routine evaluations for TB diagnosis. Demographic data, medical history, signs, and symptoms were recorded. Participants were followed up for 2 months for final ascertainment of TB diagnosis. Results: Of 206 patients, 37 (18%) had TB. Four clinical predictors were identified: low body mass index (< 19 kg/m2), prolonged cough (duration. > 2 weeks), shaking chills (≥ 1 week), and no use of antiretrovirals. The area under the receiver operating curve was 90.2%; adding the ICT-TB test result increased the area nonsignificantly to 91.6% (P =0.40). When patients were categorized by risk scores derived from selected clinical predictors into low (scores ≤ 7) and high (scores. > 7) TB risk groups, a positive ICT-TB test increased the positive predictive value nonsignificantly in the low risk group (from 12.5% to 27.3%, P =0.17) and the high risk group (from 78.6% to 80.8%, P =0.73). Conclusion: In this study setting, the ICT-TB test did not enhance TB diagnosis over the four clinical predictors in the overall group or any subgroups of HIV patients classified by clinical risk scores. © 2011 Nanta et al. 2014-08-30T02:25:38Z 2014-08-30T02:25:38Z 2011 Article 11791349 10.2147/CLEP.S24668 http://www.scopus.com/inward/record.url?eid=2-s2.0-80955160045&partnerID=40&md5=6901f5888a6840284a94555b093b326d http://www.ncbi.nlm.nih.gov/pubmed/22003307 http://cmuir.cmu.ac.th/handle/6653943832/2999 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Purpose: The value of an immunochromatographic test for tuberculosis (ICT-TB) combined with clinical predictors has yet to be evaluated in Thailand. This study aimed to assess any additional diagnostic value of an ICT-TB test over that of clinical predictors in a group of human immunodeficiency virus (HIV) patients as well as in subgroups of HIV patients classified by clinical risk scores. Patients and methods: An extended cross-sectional study was conducted at a community hospital in Chiang Rai and a general hospital in Lampang. HIV patients registered between April 2009 and May 2010 were screened by a locally made ICT-TB test, including 38, 16, and 6 kD Microbacterium tuberculosis antigens, as well as by routine evaluations for TB diagnosis. Demographic data, medical history, signs, and symptoms were recorded. Participants were followed up for 2 months for final ascertainment of TB diagnosis. Results: Of 206 patients, 37 (18%) had TB. Four clinical predictors were identified: low body mass index (< 19 kg/m2), prolonged cough (duration. > 2 weeks), shaking chills (≥ 1 week), and no use of antiretrovirals. The area under the receiver operating curve was 90.2%; adding the ICT-TB test result increased the area nonsignificantly to 91.6% (P =0.40). When patients were categorized by risk scores derived from selected clinical predictors into low (scores ≤ 7) and high (scores. > 7) TB risk groups, a positive ICT-TB test increased the positive predictive value nonsignificantly in the low risk group (from 12.5% to 27.3%, P =0.17) and the high risk group (from 78.6% to 80.8%, P =0.73). Conclusion: In this study setting, the ICT-TB test did not enhance TB diagnosis over the four clinical predictors in the overall group or any subgroups of HIV patients classified by clinical risk scores. © 2011 Nanta et al.
format Article
author Nanta S.
Kantipong P.
Pathipvanich P.
Ruengorn C.
Tawichasri C.
Patumanond J.
spellingShingle Nanta S.
Kantipong P.
Pathipvanich P.
Ruengorn C.
Tawichasri C.
Patumanond J.
Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients
author_facet Nanta S.
Kantipong P.
Pathipvanich P.
Ruengorn C.
Tawichasri C.
Patumanond J.
author_sort Nanta S.
title Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients
title_short Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients
title_full Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients
title_fullStr Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients
title_full_unstemmed Diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in HIV patients
title_sort diagnostic value of an immunochromatographic test over clinical predictors for tuberculosis in hiv patients
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-80955160045&partnerID=40&md5=6901f5888a6840284a94555b093b326d
http://www.ncbi.nlm.nih.gov/pubmed/22003307
http://cmuir.cmu.ac.th/handle/6653943832/2999
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