Epstein-Barr virus-associated smooth muscle tumor of the tonsil

• Main Authors: Suwansirikul S., Sukpan K., Sittitrai P., Suwiwat S., Khunamornpong S.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-80052100090&partnerID=40&md5=c043302157b4f06c1aec416b4f3e2847; http://www.ncbi.nlm.nih.gov/pubmed/21885224; http://cmuir.cmu.ac.th/handle/6653943832/3005
• Institution: Chiang Mai University

Smooth muscle tumors of the tonsil are rare. Recently, the occurrence of Epstein-Barr virus-associated smooth muscle tumor (EBV-SMT) has been increasingly recognized in immunocompromised patients, mainly post-transplantation and AIDS patients. The clinicopathologic features of EBV-SMT are different from conventional smooth muscle tumors. To the best of our knowledge, EBV-SMT involving the tonsil in an AIDS patient has not been reported. A 27-year-old man presented with a 2.2 cm right tonsillar mass six months after AIDS diagnosis. The tumor was composed of a cellular proliferation of oval to spindle-shaped cells with mitotic count up to 10 in 10 high-power fields. The diagnosis of EBV-SMT was confirmed by in situ hybridization for EBV-encoded RNA (EBER) transcripts. Synchronous lesions were also detected in the liver and peritoneum by an abdominal computed tomographic scan. EBV-SMT should be included in the differential diagnoses of a mesenchymal tumor in immunocompromised patients, and in the differential diagnoses of a smooth muscle tumor occurring in uncommon sites including the tonsil. © 2011 Elsevier Ireland Ltd. All rights reserved.