PPARγ agonist improves neuronal insulin receptor function in hippocampus and brain mitochondria function in rats with insulin resistance induced by long term high-fat diets

• Main Authors: Pipatpiboon N., Pratchayasakul W., Chattipakorn N., Chattipakorn S.C.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-84455185141&partnerID=40&md5=eca9db9192df478a7c7ae8e8dc2938fd; http://www.ncbi.nlm.nih.gov/pubmed/22109891; http://cmuir.cmu.ac.th/handle/6653943832/3019
• Institution: Chiang Mai University

We previously demonstrated that a high-fat diet (HFD) consumption can cause not only peripheral insulin resistance, but also neuronal insulin resistance. Moreover, the consumption of an HFD has been shown to cause mitochondrial dysfunction in both the skeletal muscle and liver. Rosiglitazone, a pero...