Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure
This study evaluated the utility of single and combined measurements of cadmium toxicity markers for surveillance purposes, using a sample of 224 individuals, 30-87 years of age, who were residents of cadmium polluted area in Mae Sot District, Tak Province, Thailand. Urinary cadmium levels excreted...
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th-cmuir.6653943832-31502014-08-30T02:25:49Z Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure Teeyakasem W. Nishijo M. Honda R. Satarug S. Swaddiwudhipong W. Ruangyuttikarn W. This study evaluated the utility of single and combined measurements of cadmium toxicity markers for surveillance purposes, using a sample of 224 individuals, 30-87 years of age, who were residents of cadmium polluted area in Mae Sot District, Tak Province, Thailand. Urinary cadmium levels excreted by them ranged between 1 and 58 microg/g creatinine with geometric mean of 8.2 microg/g creatinine which was 16-fold greater than the average for the general Thai population of 0.5 microg/g creatinine. The urinary markers evaluated were total protein, albumin, N-acetyl-beta-D-glucosaminidase (NAG), lysozyme, beta2-microglobulin (beta2-MG) and alpha1-microglobulin (alpha1-MG). Among these markers, only NAG showed a positive correlation with urinary cadmium in both male and female subjects with and without disease (r=0.43-0.71). Further, the prevalence rates for urinary NAG above 8 units/g creatinine (NAG-uria) increased with exposure levels in a dose dependent manner (p=0.05) among subjects with disease. In contrast, however, increased prevalence of beta2-MG above 0.4 mg/g creatinine (beta2-MG-uria) was associated with cadmium above 5 microg/g creatinine only in those without disease (POR=10.6 and 7.8 for 6-10 and >10 microg/g creatinine). Prevalence rates for abnormal excretion of all other markers, except albumin, were markedly increased among those having beta2-MG-uria with and without disease (chi2-test, p<or=0.001-0.02). Thus, urinary beta2-MG and NAG should be used together with urinary cadmium in the monitoring of renal toxicity in a population exposed to high-level cadmium coupled with high prevalence of chronic diseases. 2014-08-30T02:25:49Z 2014-08-30T02:25:49Z 2007 Journal Article 0378-4274 17306939 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3150 eng |
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This study evaluated the utility of single and combined measurements of cadmium toxicity markers for surveillance purposes, using a sample of 224 individuals, 30-87 years of age, who were residents of cadmium polluted area in Mae Sot District, Tak Province, Thailand. Urinary cadmium levels excreted by them ranged between 1 and 58 microg/g creatinine with geometric mean of 8.2 microg/g creatinine which was 16-fold greater than the average for the general Thai population of 0.5 microg/g creatinine. The urinary markers evaluated were total protein, albumin, N-acetyl-beta-D-glucosaminidase (NAG), lysozyme, beta2-microglobulin (beta2-MG) and alpha1-microglobulin (alpha1-MG). Among these markers, only NAG showed a positive correlation with urinary cadmium in both male and female subjects with and without disease (r=0.43-0.71). Further, the prevalence rates for urinary NAG above 8 units/g creatinine (NAG-uria) increased with exposure levels in a dose dependent manner (p=0.05) among subjects with disease. In contrast, however, increased prevalence of beta2-MG above 0.4 mg/g creatinine (beta2-MG-uria) was associated with cadmium above 5 microg/g creatinine only in those without disease (POR=10.6 and 7.8 for 6-10 and >10 microg/g creatinine). Prevalence rates for abnormal excretion of all other markers, except albumin, were markedly increased among those having beta2-MG-uria with and without disease (chi2-test, p<or=0.001-0.02). Thus, urinary beta2-MG and NAG should be used together with urinary cadmium in the monitoring of renal toxicity in a population exposed to high-level cadmium coupled with high prevalence of chronic diseases. |
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Article |
author |
Teeyakasem W. Nishijo M. Honda R. Satarug S. Swaddiwudhipong W. Ruangyuttikarn W. |
spellingShingle |
Teeyakasem W. Nishijo M. Honda R. Satarug S. Swaddiwudhipong W. Ruangyuttikarn W. Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure |
author_facet |
Teeyakasem W. Nishijo M. Honda R. Satarug S. Swaddiwudhipong W. Ruangyuttikarn W. |
author_sort |
Teeyakasem W. |
title |
Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure |
title_short |
Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure |
title_full |
Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure |
title_fullStr |
Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure |
title_full_unstemmed |
Monitoring of cadmium toxicity in a Thai population with high-level environmental exposure |
title_sort |
monitoring of cadmium toxicity in a thai population with high-level environmental exposure |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3150 |
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1681419994155450368 |