Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn
Cissus quadrangularis, a medicinal plant indigenous to Asia and Africa, is used for many ailments, especially for the treatment of hemorrhoid. The effects associated with hemorrhoid, i.e. analgesic and anti-inflammatory activities as well as the venotonic effect of the methanol extract of C. quadran...
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2014
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th-cmuir.6653943832-31622014-08-30T02:25:50Z Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn Panthong A. Supraditaporn W. Kanjanapothi D. Taesotikul T. Reutrakul V. Cissus quadrangularis, a medicinal plant indigenous to Asia and Africa, is used for many ailments, especially for the treatment of hemorrhoid. The effects associated with hemorrhoid, i.e. analgesic and anti-inflammatory activities as well as the venotonic effect of the methanol extract of C. quadrangularis (CQ) were assessed in comparison with reference drugs. In the analgesic test, CQ provoked a significant reduction of the number of writhes in acetic acid-induced writhing response in mice. CQ also significantly reduced the licking time in both phases of the formalin test. The results suggest peripheral and central analgesic activity of CQ. In acute phase of inflammation CQ elicited the inhibitory effect on the edema formation of the rats' ear induced by ethyl phenylpropiolate as well as on the formation of the paw edema in rats induced by both carrageenin and arachidonic acid. It is likely that CQ is a dual inhibitor of arachidonic acid metabolism. In addition, CQ exerted venotonic effect on isolated human umbilical vein similarly to the mixture of bioflavonoids, i.e. 90% diosmin and 10% hesperidin. The results obtained confirmed the traditional use of C. quadrangularis for the treatment of pain and inflammation associated with hemorrhoid as well as reducing the size of hemorrhoids. 2014-08-30T02:25:50Z 2014-08-30T02:25:50Z 2007 Comparative Study 0378-8741 17095173 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3162 eng |
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Cissus quadrangularis, a medicinal plant indigenous to Asia and Africa, is used for many ailments, especially for the treatment of hemorrhoid. The effects associated with hemorrhoid, i.e. analgesic and anti-inflammatory activities as well as the venotonic effect of the methanol extract of C. quadrangularis (CQ) were assessed in comparison with reference drugs. In the analgesic test, CQ provoked a significant reduction of the number of writhes in acetic acid-induced writhing response in mice. CQ also significantly reduced the licking time in both phases of the formalin test. The results suggest peripheral and central analgesic activity of CQ. In acute phase of inflammation CQ elicited the inhibitory effect on the edema formation of the rats' ear induced by ethyl phenylpropiolate as well as on the formation of the paw edema in rats induced by both carrageenin and arachidonic acid. It is likely that CQ is a dual inhibitor of arachidonic acid metabolism. In addition, CQ exerted venotonic effect on isolated human umbilical vein similarly to the mixture of bioflavonoids, i.e. 90% diosmin and 10% hesperidin. The results obtained confirmed the traditional use of C. quadrangularis for the treatment of pain and inflammation associated with hemorrhoid as well as reducing the size of hemorrhoids. |
format |
Comparative Study |
author |
Panthong A. Supraditaporn W. Kanjanapothi D. Taesotikul T. Reutrakul V. |
spellingShingle |
Panthong A. Supraditaporn W. Kanjanapothi D. Taesotikul T. Reutrakul V. Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn |
author_facet |
Panthong A. Supraditaporn W. Kanjanapothi D. Taesotikul T. Reutrakul V. |
author_sort |
Panthong A. |
title |
Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn |
title_short |
Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn |
title_full |
Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn |
title_fullStr |
Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn |
title_full_unstemmed |
Analgesic, anti-inflammatory and venotonic effects of Cissus quadrangularis Linn |
title_sort |
analgesic, anti-inflammatory and venotonic effects of cissus quadrangularis linn |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3162 |
_version_ |
1681419996435054592 |