The risk of residual neoplasia in women with microinvasive squamous cervical carcinoma and positive cone margins

The objective was to evaluate the prevalence and factors affecting residual disease in women with cervical microinvasive carcinoma (MIC) with positive cone margins for high-grade lesions and invasive carcinoma. We reviewed histopathology slides of 129 women with MIC who had high-grade lesions or inv...

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Main Authors: Phongnarisorn C., Srisomboon J., Khunamornpong S., Siriaungkul S., Suprasert P., Charoenkwan K., Cheewakriangkrai C., Siriaree S., Pantasri T.
Format: Article
Language:English
Published: 2014
Online Access:http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3194
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-31942014-08-30T02:25:52Z The risk of residual neoplasia in women with microinvasive squamous cervical carcinoma and positive cone margins Phongnarisorn C. Srisomboon J. Khunamornpong S. Siriaungkul S. Suprasert P. Charoenkwan K. Cheewakriangkrai C. Siriaree S. Pantasri T. The objective was to evaluate the prevalence and factors affecting residual disease in women with cervical microinvasive carcinoma (MIC) with positive cone margins for high-grade lesions and invasive carcinoma. We reviewed histopathology slides of 129 women with MIC who had high-grade lesions or invasive carcinoma at cone margins. These patients underwent hysterectomy following cone biopsy between January 1994 and June 2004. Of the 129 patients, 77 (59.7%) had residual disease in the hysterectomy specimens, in which 57 (44.2%) had residual high-grade lesions. Twenty patients (15.5%) had residual invasive carcinoma: 18 were microinvasive and 2 were invasive. Factors significantly affecting the risk of residual disease included positive postconization endocervical curettage (P= 0.001), positive cone margins for invasive carcinoma (P= 0.003), and depth of stromal invasion >1 mm (P= 0.014). Cox proportional hazards analysis revealed positive cone margins for invasive carcinoma as significant predictor of residual invasive disease (hazard ratio, 3.22; 95% CI 1.21-8.60, P= 0.019) In summary, patients with MIC and positive cone margins for high-grade lesions or invasive carcinoma are at high risk of residual neoplasia. Repeat cone biopsy should be performed to determine exactly the severity of lesion before planning treatment. 2014-08-30T02:25:52Z 2014-08-30T02:25:52Z Journal Article 1048-891X 16681742 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3194 eng
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description The objective was to evaluate the prevalence and factors affecting residual disease in women with cervical microinvasive carcinoma (MIC) with positive cone margins for high-grade lesions and invasive carcinoma. We reviewed histopathology slides of 129 women with MIC who had high-grade lesions or invasive carcinoma at cone margins. These patients underwent hysterectomy following cone biopsy between January 1994 and June 2004. Of the 129 patients, 77 (59.7%) had residual disease in the hysterectomy specimens, in which 57 (44.2%) had residual high-grade lesions. Twenty patients (15.5%) had residual invasive carcinoma: 18 were microinvasive and 2 were invasive. Factors significantly affecting the risk of residual disease included positive postconization endocervical curettage (P= 0.001), positive cone margins for invasive carcinoma (P= 0.003), and depth of stromal invasion >1 mm (P= 0.014). Cox proportional hazards analysis revealed positive cone margins for invasive carcinoma as significant predictor of residual invasive disease (hazard ratio, 3.22; 95% CI 1.21-8.60, P= 0.019) In summary, patients with MIC and positive cone margins for high-grade lesions or invasive carcinoma are at high risk of residual neoplasia. Repeat cone biopsy should be performed to determine exactly the severity of lesion before planning treatment.
format Article
author Phongnarisorn C.
Srisomboon J.
Khunamornpong S.
Siriaungkul S.
Suprasert P.
Charoenkwan K.
Cheewakriangkrai C.
Siriaree S.
Pantasri T.
spellingShingle Phongnarisorn C.
Srisomboon J.
Khunamornpong S.
Siriaungkul S.
Suprasert P.
Charoenkwan K.
Cheewakriangkrai C.
Siriaree S.
Pantasri T.
The risk of residual neoplasia in women with microinvasive squamous cervical carcinoma and positive cone margins
author_facet Phongnarisorn C.
Srisomboon J.
Khunamornpong S.
Siriaungkul S.
Suprasert P.
Charoenkwan K.
Cheewakriangkrai C.
Siriaree S.
Pantasri T.
author_sort Phongnarisorn C.
title The risk of residual neoplasia in women with microinvasive squamous cervical carcinoma and positive cone margins
title_short The risk of residual neoplasia in women with microinvasive squamous cervical carcinoma and positive cone margins
title_full The risk of residual neoplasia in women with microinvasive squamous cervical carcinoma and positive cone margins
title_fullStr The risk of residual neoplasia in women with microinvasive squamous cervical carcinoma and positive cone margins
title_full_unstemmed The risk of residual neoplasia in women with microinvasive squamous cervical carcinoma and positive cone margins
title_sort risk of residual neoplasia in women with microinvasive squamous cervical carcinoma and positive cone margins
publishDate 2014
url http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3194
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