Curcuminoids purified from turmeric powder modulate the function of human multidrug resistance protein 1 (ABCC1)

• Main Authors: Chearwae W., Wu CP., Chu HY., Lee TR., Ambudkar SV., Limtrakul P.
• 格式: Comparative Study
• 語言: English
• 出版: 2014
• 在線閱讀: http://www.ncbi.nlm.nih.gov/pubmed/3502482; http://cmuir.cmu.ac.th/handle/6653943832/3232

Multidrug resistance is a major cause of chemotherapy failure in cancer patients. One of the resistance mechanisms is the overexpression of drug efflux pumps such as P-glycoprotein and multidrug resistance protein 1 (MRP1, (ABCC1)). In this study, curcumin mixture and three major curcuminoids purifi...