Preterm labour management--an evidence--update

Preterm birth is the leading cause of perinatal mortality and morbidity. Biologic markers, fetal fibronectin and transvaginal ultrasound scanning, have been introduced to identify the risk of preterm birth. The aim of management of preterm labour is to reduce neonatal complications. Various groups o...

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Main Author: Piyamongkol W.
Format: Article
Language:English
Published: 2014
Online Access:http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3243
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-32432014-08-30T02:25:55Z Preterm labour management--an evidence--update Piyamongkol W. Preterm birth is the leading cause of perinatal mortality and morbidity. Biologic markers, fetal fibronectin and transvaginal ultrasound scanning, have been introduced to identify the risk of preterm birth. The aim of management of preterm labour is to reduce neonatal complications. Various groups of tocolytic agents have been used, including beta-adrenergic agonists, calcium channel blockers, magnesium sulphate, prostaglandin synthetase inhibitors and oxytocin receptor antagonists. Beta-adrenergic agonists, the most widely used tocolytic agent, seem to show significant serious side effects. Calcium channel blockers and oxytocin receptor antagonists provide comparable efficacy to beta-adrenergic agonists, while giving fewer adverse effects. However calcium channel blockers are cheaper and more convenient to administer During 28-34 weeks of gestation, it is recommended to use tocolytics just for the first 24-48 hours waiting for fetal lung maturity after corticosteroid treatment or in utero transfer. Maintenance therapy of tocolytics is not useful in prolongation of pregnancy and does not improve perinatal outcomes. After 34 weeks of gestation there is no benefit of prolongation of the pregnancy. A single course of corticosteroid treatment is effective in preventing respiratory distress syndrome during 28-34 weeks of gestation. However, repeated treatment as a weekly course seems to do more harm than good. 2014-08-30T02:25:55Z 2014-08-30T02:25:55Z 2004 Journal Article 0125-2208 21213513 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3243 eng
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Preterm birth is the leading cause of perinatal mortality and morbidity. Biologic markers, fetal fibronectin and transvaginal ultrasound scanning, have been introduced to identify the risk of preterm birth. The aim of management of preterm labour is to reduce neonatal complications. Various groups of tocolytic agents have been used, including beta-adrenergic agonists, calcium channel blockers, magnesium sulphate, prostaglandin synthetase inhibitors and oxytocin receptor antagonists. Beta-adrenergic agonists, the most widely used tocolytic agent, seem to show significant serious side effects. Calcium channel blockers and oxytocin receptor antagonists provide comparable efficacy to beta-adrenergic agonists, while giving fewer adverse effects. However calcium channel blockers are cheaper and more convenient to administer During 28-34 weeks of gestation, it is recommended to use tocolytics just for the first 24-48 hours waiting for fetal lung maturity after corticosteroid treatment or in utero transfer. Maintenance therapy of tocolytics is not useful in prolongation of pregnancy and does not improve perinatal outcomes. After 34 weeks of gestation there is no benefit of prolongation of the pregnancy. A single course of corticosteroid treatment is effective in preventing respiratory distress syndrome during 28-34 weeks of gestation. However, repeated treatment as a weekly course seems to do more harm than good.
format Article
author Piyamongkol W.
spellingShingle Piyamongkol W.
Preterm labour management--an evidence--update
author_facet Piyamongkol W.
author_sort Piyamongkol W.
title Preterm labour management--an evidence--update
title_short Preterm labour management--an evidence--update
title_full Preterm labour management--an evidence--update
title_fullStr Preterm labour management--an evidence--update
title_full_unstemmed Preterm labour management--an evidence--update
title_sort preterm labour management--an evidence--update
publishDate 2014
url http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3243
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