Analysis of beta-thalassemia mutations in northern Thailand using an automated fluorescence DNA sequencing technique

• المؤلفون الرئيسيون: Sirichotiyakul S., Saetung R., Sanguansermsri T.
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الوصول للمادة أونلاين: http://www.ncbi.nlm.nih.gov/pubmed/3502482; http://cmuir.cmu.ac.th/handle/6653943832/3258
• المؤسسة: Chiang Mai University

A total of 218 beta-thalassemia (thal) genes from 109 beta-thal major patients were characterized using an automated fluorescence DNA sequencing technique. Eight different mutations were identified in all 218 alleles (100%). Four common mutations accounted for 96.8% [49.5% were codons 41/42 (-TTCT),...