Bioequivalence study of generic acyclovir compared with the brand name acyclovir
The bioequivalence study of 200-mg generic acyclovir was conducted in healthy males. The reference Zovirax and the test Zevin were administered as a single oral dose after an overnight fast in a two-period, crossover design separated by 1 week. Serial blood samples were collected over a period of 24...
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th-cmuir.6653943832-32662014-08-30T02:25:56Z Bioequivalence study of generic acyclovir compared with the brand name acyclovir Rojanasthien N. Teekachunhatean S. Kumsorn B. Chaichana N. Hay YK. The bioequivalence study of 200-mg generic acyclovir was conducted in healthy males. The reference Zovirax and the test Zevin were administered as a single oral dose after an overnight fast in a two-period, crossover design separated by 1 week. Serial blood samples were collected over a period of 24 hours. Plasma acyclovir concentrations were determined by HPLC and the pharmacokinetic parameters were analyzed by non-compartmental analysis. RESULTS: The t 1/2 for the test (4.5 +/- 2.4 h) and Zoviraxl (3.9 +/- 2.6 h) were comparable. The analysis of variance was carried out and the median Tmax (1.50 h) for the test was not statistically difference from Zovirax. The mean (90% CI) of the AUC0-infinity and the Cmax ratios for (Test/reference) were 0.95 (0.83-1.09) and 0.95 (0.83-1.10), respectively. These values fell within the bioequivalence criteria of 0.80-1.25, thus it was concluded that Zevin and Zovirax were bioequivalence. 2014-08-30T02:25:56Z 2014-08-30T02:25:56Z 2002 Journal Article 0125-2208 12501905 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3266 eng |
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The bioequivalence study of 200-mg generic acyclovir was conducted in healthy males. The reference Zovirax and the test Zevin were administered as a single oral dose after an overnight fast in a two-period, crossover design separated by 1 week. Serial blood samples were collected over a period of 24 hours. Plasma acyclovir concentrations were determined by HPLC and the pharmacokinetic parameters were analyzed by non-compartmental analysis. RESULTS: The t 1/2 for the test (4.5 +/- 2.4 h) and Zoviraxl (3.9 +/- 2.6 h) were comparable. The analysis of variance was carried out and the median Tmax (1.50 h) for the test was not statistically difference from Zovirax. The mean (90% CI) of the AUC0-infinity and the Cmax ratios for (Test/reference) were 0.95 (0.83-1.09) and 0.95 (0.83-1.10), respectively. These values fell within the bioequivalence criteria of 0.80-1.25, thus it was concluded that Zevin and Zovirax were bioequivalence. |
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Article |
author |
Rojanasthien N. Teekachunhatean S. Kumsorn B. Chaichana N. Hay YK. |
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Rojanasthien N. Teekachunhatean S. Kumsorn B. Chaichana N. Hay YK. Bioequivalence study of generic acyclovir compared with the brand name acyclovir |
author_facet |
Rojanasthien N. Teekachunhatean S. Kumsorn B. Chaichana N. Hay YK. |
author_sort |
Rojanasthien N. |
title |
Bioequivalence study of generic acyclovir compared with the brand name acyclovir |
title_short |
Bioequivalence study of generic acyclovir compared with the brand name acyclovir |
title_full |
Bioequivalence study of generic acyclovir compared with the brand name acyclovir |
title_fullStr |
Bioequivalence study of generic acyclovir compared with the brand name acyclovir |
title_full_unstemmed |
Bioequivalence study of generic acyclovir compared with the brand name acyclovir |
title_sort |
bioequivalence study of generic acyclovir compared with the brand name acyclovir |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3266 |
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