Pharmacokinetics and bioequivalence testing of generic ondansetron preparations in healthy Thai male volunteers
Pharmacokinetics and bioequivalence of oral preparations of generic ondansetron were investigated in healthy Thai males. The test preparations were Vomitron 8 and Vomitron 4, the reference was Zofran. The three products were administered as an 8 mg single oral dose, in a three-period four-sequence c...
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| Format: | Clinical Trial |
| Language: | English |
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2014
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| Online Access: | http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3352 |
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th-cmuir.6653943832-33522014-08-30T02:26:02Z Pharmacokinetics and bioequivalence testing of generic ondansetron preparations in healthy Thai male volunteers Rojanasthien N. Manorot M. Kumsorn B. Pharmacokinetics and bioequivalence of oral preparations of generic ondansetron were investigated in healthy Thai males. The test preparations were Vomitron 8 and Vomitron 4, the reference was Zofran. The three products were administered as an 8 mg single oral dose, in a three-period four-sequence cross-over design with one-week washout period. An intravenous 8 mg Zofran was administered on the forth visit. Plasma ondansetron concentrations were determined by HPLC and the pharmacokinetic parameters were analyzed by non-compartmental analysis. 2014-08-30T02:26:02Z 2014-08-30T02:26:02Z 1999 Clinical Trial 0946-1965 10584976 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3352 eng |
| institution |
Chiang Mai University |
| building |
Chiang Mai University Library |
| country |
Thailand |
| collection |
CMU Intellectual Repository |
| language |
English |
| description |
Pharmacokinetics and bioequivalence of oral preparations of generic ondansetron were investigated in healthy Thai males. The test preparations were Vomitron 8 and Vomitron 4, the reference was Zofran. The three products were administered as an 8 mg single oral dose, in a three-period four-sequence cross-over design with one-week washout period. An intravenous 8 mg Zofran was administered on the forth visit. Plasma ondansetron concentrations were determined by HPLC and the pharmacokinetic parameters were analyzed by non-compartmental analysis. |
| format |
Clinical Trial |
| author |
Rojanasthien N. Manorot M. Kumsorn B. |
| spellingShingle |
Rojanasthien N. Manorot M. Kumsorn B. Pharmacokinetics and bioequivalence testing of generic ondansetron preparations in healthy Thai male volunteers |
| author_facet |
Rojanasthien N. Manorot M. Kumsorn B. |
| author_sort |
Rojanasthien N. |
| title |
Pharmacokinetics and bioequivalence testing of generic ondansetron preparations in healthy Thai male volunteers |
| title_short |
Pharmacokinetics and bioequivalence testing of generic ondansetron preparations in healthy Thai male volunteers |
| title_full |
Pharmacokinetics and bioequivalence testing of generic ondansetron preparations in healthy Thai male volunteers |
| title_fullStr |
Pharmacokinetics and bioequivalence testing of generic ondansetron preparations in healthy Thai male volunteers |
| title_full_unstemmed |
Pharmacokinetics and bioequivalence testing of generic ondansetron preparations in healthy Thai male volunteers |
| title_sort |
pharmacokinetics and bioequivalence testing of generic ondansetron preparations in healthy thai male volunteers |
| publishDate |
2014 |
| url |
http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3352 |
| _version_ |
1681420032048889856 |