Gentamicin pharmacokinetics in Thai neonates: recommendation for a dosing guideline
A pharmacokinetic study of gentamicin was performed on 32 Thai neonates. After a single intravenous infusion of gentamicin at 2.5 mg/kg body weight, blood samples were collected at 0.5 and 12 hours. Serum gentamicin concentrations were determined with use of fluorescence polarizing immunoassay. None...
Saved in:
Main Authors: | , , |
---|---|
Format: | Clinical Trial |
Language: | English |
Published: |
2014
|
Online Access: | http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3416 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Chiang Mai University |
Language: | English |
id |
th-cmuir.6653943832-3416 |
---|---|
record_format |
dspace |
spelling |
th-cmuir.6653943832-34162014-08-30T02:26:06Z Gentamicin pharmacokinetics in Thai neonates: recommendation for a dosing guideline Kanthawatana S. Uruwannakul K. Chotinarumon S. A pharmacokinetic study of gentamicin was performed on 32 Thai neonates. After a single intravenous infusion of gentamicin at 2.5 mg/kg body weight, blood samples were collected at 0.5 and 12 hours. Serum gentamicin concentrations were determined with use of fluorescence polarizing immunoassay. None of the neonates with < 28 weeks post conceptional age (PCA), contrary to most of the more mature neonates, achieved the recommended therapeutic peak concentrations. The volume of distribution (Vd) and elimination half-life (T1/2) of gentamicin were found to reversely correlate with the PCA, with significantly larger Vd and longer T1/2 values observed among the premature neonates. Our findings were similar the results previously reported in Caucasians, and thus strongly indicated the necessity of gentamicin dosage adjustment among Thai neonates according to their PCA. A gentamicin dosing guideline for Thai neonates has been proposed, nonetheless, with higher doses and longer dosing intervals recommended among premature neonates. 2014-08-30T02:26:06Z 2014-08-30T02:26:06Z 1998 Clinical Trial 0125-2208 9529844 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3416 eng |
institution |
Chiang Mai University |
building |
Chiang Mai University Library |
country |
Thailand |
collection |
CMU Intellectual Repository |
language |
English |
description |
A pharmacokinetic study of gentamicin was performed on 32 Thai neonates. After a single intravenous infusion of gentamicin at 2.5 mg/kg body weight, blood samples were collected at 0.5 and 12 hours. Serum gentamicin concentrations were determined with use of fluorescence polarizing immunoassay. None of the neonates with < 28 weeks post conceptional age (PCA), contrary to most of the more mature neonates, achieved the recommended therapeutic peak concentrations. The volume of distribution (Vd) and elimination half-life (T1/2) of gentamicin were found to reversely correlate with the PCA, with significantly larger Vd and longer T1/2 values observed among the premature neonates. Our findings were similar the results previously reported in Caucasians, and thus strongly indicated the necessity of gentamicin dosage adjustment among Thai neonates according to their PCA. A gentamicin dosing guideline for Thai neonates has been proposed, nonetheless, with higher doses and longer dosing intervals recommended among premature neonates. |
format |
Clinical Trial |
author |
Kanthawatana S. Uruwannakul K. Chotinarumon S. |
spellingShingle |
Kanthawatana S. Uruwannakul K. Chotinarumon S. Gentamicin pharmacokinetics in Thai neonates: recommendation for a dosing guideline |
author_facet |
Kanthawatana S. Uruwannakul K. Chotinarumon S. |
author_sort |
Kanthawatana S. |
title |
Gentamicin pharmacokinetics in Thai neonates: recommendation for a dosing guideline |
title_short |
Gentamicin pharmacokinetics in Thai neonates: recommendation for a dosing guideline |
title_full |
Gentamicin pharmacokinetics in Thai neonates: recommendation for a dosing guideline |
title_fullStr |
Gentamicin pharmacokinetics in Thai neonates: recommendation for a dosing guideline |
title_full_unstemmed |
Gentamicin pharmacokinetics in Thai neonates: recommendation for a dosing guideline |
title_sort |
gentamicin pharmacokinetics in thai neonates: recommendation for a dosing guideline |
publishDate |
2014 |
url |
http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3416 |
_version_ |
1681420044003704832 |