The analgesic, antipyretic and anti-inflammatory activity of Diospyros variegata Kruz.

• Main Authors: Trongsakul S., Panthong A., Kanjanapothi D., Taesotikul T.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-0037375077&partnerID=40&md5=03a919a8015ebbfe8b55caec40404df4; http://cmuir.cmu.ac.th/handle/6653943832/3432
• Institution: Chiang Mai University

Pharmacological studies were conducted with the hexane extract of the dry stem of Diospyros variegata Kruz. (Ebenaceae) on experimental animals for evaluating the analgesic, antipyretic and anti-inflammatory activities. In the analgesic test, the hexane extract elicited inhibitory intensity on acetic acid-induced writhing response and on the late phase of formalin test but possessed only a weak effect on the tail-flick response and on the early phase of formalin test. The hexane extract also elicited antipyretic action when tested in yeast-induced hyperthermia in rats. In addition, the hexane extract showed an anti-inflammatory effect when tested in ethyl phenylpropiolate (EPP)- and arachidonic acid (AA)-induced rat ear edema. © 2003 Elsevier Science Ireland Ltd. All rights reserved.