Disseminated Penicillium marneffei infection in human immunodeficiency virus-infected children

Disseminated infection with the fungus Penicillium marneffei is one of the most common opportunistic infections in human immunodeficiency virus (HIV) disease in northern Thailand. We report the clinical, laboratory and therapeutic features of 21 human immunodeficiency virus-infected children with di...

Full description

Saved in:
Bibliographic Details
Main Authors: Sirisanthana V., Sirisanthana T.
Format: Article
Language:English
Published: 2014
Online Access:http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3464
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
Language: English
id th-cmuir.6653943832-3464
record_format dspace
spelling th-cmuir.6653943832-34642014-08-30T02:26:08Z Disseminated Penicillium marneffei infection in human immunodeficiency virus-infected children Sirisanthana V. Sirisanthana T. Disseminated infection with the fungus Penicillium marneffei is one of the most common opportunistic infections in human immunodeficiency virus (HIV) disease in northern Thailand. We report the clinical, laboratory and therapeutic features of 21 human immunodeficiency virus-infected children with disseminated P. marneffei who were prospectively followed. Significant clinical and laboratory features included generalized lymphadenopathy (90%), hepatomegaly (90%), body temperature > 38.5 degrees C (81%), papular skin lesions with central umbilication (67%), splenomegaly (67%), failure to thrive (52%), severe anemia (hemoglobin < 60 g/liter) (43%) and thrombocytopenia (platelet count < 0.5 x 10(11)/liter) (21%). The response rate in patients who were treated with appropriate antifungal therapy (amphotericin B, fluconazole or ketoconazole) was 82%. No relapse was observed in patients given ketoconazole prophylactically. Skin lesions, usually papules with central necrotic umbilication, provide the most significant clue to the diagnosis. Early diagnosis based on finding P. marneffei in the skin smear or lymph node provides the basis for prompt administration of antifungal therapy and improved outcome. 2014-08-30T02:26:08Z 2014-08-30T02:26:08Z 1995 Journal Article 0891-3668 8584358 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3464 eng
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Disseminated infection with the fungus Penicillium marneffei is one of the most common opportunistic infections in human immunodeficiency virus (HIV) disease in northern Thailand. We report the clinical, laboratory and therapeutic features of 21 human immunodeficiency virus-infected children with disseminated P. marneffei who were prospectively followed. Significant clinical and laboratory features included generalized lymphadenopathy (90%), hepatomegaly (90%), body temperature > 38.5 degrees C (81%), papular skin lesions with central umbilication (67%), splenomegaly (67%), failure to thrive (52%), severe anemia (hemoglobin < 60 g/liter) (43%) and thrombocytopenia (platelet count < 0.5 x 10(11)/liter) (21%). The response rate in patients who were treated with appropriate antifungal therapy (amphotericin B, fluconazole or ketoconazole) was 82%. No relapse was observed in patients given ketoconazole prophylactically. Skin lesions, usually papules with central necrotic umbilication, provide the most significant clue to the diagnosis. Early diagnosis based on finding P. marneffei in the skin smear or lymph node provides the basis for prompt administration of antifungal therapy and improved outcome.
format Article
author Sirisanthana V.
Sirisanthana T.
spellingShingle Sirisanthana V.
Sirisanthana T.
Disseminated Penicillium marneffei infection in human immunodeficiency virus-infected children
author_facet Sirisanthana V.
Sirisanthana T.
author_sort Sirisanthana V.
title Disseminated Penicillium marneffei infection in human immunodeficiency virus-infected children
title_short Disseminated Penicillium marneffei infection in human immunodeficiency virus-infected children
title_full Disseminated Penicillium marneffei infection in human immunodeficiency virus-infected children
title_fullStr Disseminated Penicillium marneffei infection in human immunodeficiency virus-infected children
title_full_unstemmed Disseminated Penicillium marneffei infection in human immunodeficiency virus-infected children
title_sort disseminated penicillium marneffei infection in human immunodeficiency virus-infected children
publishDate 2014
url http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3464
_version_ 1681420053094858752