Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore

The methanol extract from Clerodendrum petasites S. Moore (CP extract) was assessed for anti-inflammatory and antipyretic activities on the experimental animal models. It was found that CP extract possessed moderate inhibitory activity on acute phase of inflammation in a dose-related manner as seen...

Full description

Saved in:
Bibliographic Details
Main Authors: Panthong A., Kanjanapothi D., Taesotikul T., Wongcome T., Reutrakul V.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-0037358280&partnerID=40&md5=70c44ef8aa04be4ea407f601cc7b966d
http://www.ncbi.nlm.nih.gov/pubmed/12576214
http://cmuir.cmu.ac.th/handle/6653943832/3474
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Chiang Mai University
Language: English
id th-cmuir.6653943832-3474
record_format dspace
spelling th-cmuir.6653943832-34742014-08-30T02:34:54Z Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore Panthong A. Kanjanapothi D. Taesotikul T. Wongcome T. Reutrakul V. The methanol extract from Clerodendrum petasites S. Moore (CP extract) was assessed for anti-inflammatory and antipyretic activities on the experimental animal models. It was found that CP extract possessed moderate inhibitory activity on acute phase of inflammation in a dose-related manner as seen in ethyl phenylpropiolate-induced ear edema (ED50=2.34mg/ear) as well as carrageenin-induced hind paw edema (ED30=420.41mg/kg) in rats. However, CP extract did not elicit any inhibitory effect on arachidonic acid-induced hind paw edema in rats. In subchronic inflammatory model, CP extract provoked a significant reduction of transudation but had no effect on proliferative phase when tested in cotton pellet-induced granuloma model. CP extract also reduced the alkaline phosphatase activity in serum of rats in this animal model. Moreover, CP extract possessed an excellent antipyretic effect when tested in yeast-induced hyperthermic rats. It is postulated that the anti-inflammatory and antipyretic effects of CP extract are caused by the inhibition of the prostaglandin synthesis. Anyhow, CP extract did not possess any analgesic activity in acetic acid-induced writhing response in mice. The results obtained show that C. petasites has beneficial properties since it possesses potent antipyretic and moderate anti-inflammatory activities without ulcerogenic effect. © 2002 Elsevier Science Ireland Ltd. All rights reserved. 2014-08-30T02:34:54Z 2014-08-30T02:34:54Z 2003 Article 03788741 10.1016/S0378-8741(02)00368-9 12576214 JOETD http://www.scopus.com/inward/record.url?eid=2-s2.0-0037358280&partnerID=40&md5=70c44ef8aa04be4ea407f601cc7b966d http://www.ncbi.nlm.nih.gov/pubmed/12576214 http://cmuir.cmu.ac.th/handle/6653943832/3474 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description The methanol extract from Clerodendrum petasites S. Moore (CP extract) was assessed for anti-inflammatory and antipyretic activities on the experimental animal models. It was found that CP extract possessed moderate inhibitory activity on acute phase of inflammation in a dose-related manner as seen in ethyl phenylpropiolate-induced ear edema (ED50=2.34mg/ear) as well as carrageenin-induced hind paw edema (ED30=420.41mg/kg) in rats. However, CP extract did not elicit any inhibitory effect on arachidonic acid-induced hind paw edema in rats. In subchronic inflammatory model, CP extract provoked a significant reduction of transudation but had no effect on proliferative phase when tested in cotton pellet-induced granuloma model. CP extract also reduced the alkaline phosphatase activity in serum of rats in this animal model. Moreover, CP extract possessed an excellent antipyretic effect when tested in yeast-induced hyperthermic rats. It is postulated that the anti-inflammatory and antipyretic effects of CP extract are caused by the inhibition of the prostaglandin synthesis. Anyhow, CP extract did not possess any analgesic activity in acetic acid-induced writhing response in mice. The results obtained show that C. petasites has beneficial properties since it possesses potent antipyretic and moderate anti-inflammatory activities without ulcerogenic effect. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
format Article
author Panthong A.
Kanjanapothi D.
Taesotikul T.
Wongcome T.
Reutrakul V.
spellingShingle Panthong A.
Kanjanapothi D.
Taesotikul T.
Wongcome T.
Reutrakul V.
Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore
author_facet Panthong A.
Kanjanapothi D.
Taesotikul T.
Wongcome T.
Reutrakul V.
author_sort Panthong A.
title Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore
title_short Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore
title_full Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore
title_fullStr Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore
title_full_unstemmed Anti-inflammatory and antipyretic properties of Clerodendrum petasites S. Moore
title_sort anti-inflammatory and antipyretic properties of clerodendrum petasites s. moore
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-0037358280&partnerID=40&md5=70c44ef8aa04be4ea407f601cc7b966d
http://www.ncbi.nlm.nih.gov/pubmed/12576214
http://cmuir.cmu.ac.th/handle/6653943832/3474
_version_ 1681420055004315648