Analysis of hepatitis C virus isolates among healthy blood donors and drug addicts in Chiang Mai, Thailand

Analysis of hepatitis C virus isolates among healthy blood donors and drug addicts in Chiang Mai, Thailand

Hepatitis C virus (HCV) isolates obtained from 25 anti-HCV antibody-positive healthy blood donors and 29 drug addicts in Chiang Mai, Thailand, were analyzed. HCV RNA was detected in 23 blood donor samples (92%) and 24 drug addict blood samples (83%) by PCR for a portion of the NS5 region. Subtype an...

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Main Authors: Apichartpiyakul C., Chittivudikarn C., Miyajima H., Homma M., Hotta H.
Format: Comparative Study
Language:English
Published: 2014
Online Access:http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3496
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-34962014-08-30T02:34:56Z Analysis of hepatitis C virus isolates among healthy blood donors and drug addicts in Chiang Mai, Thailand Apichartpiyakul C. Chittivudikarn C. Miyajima H. Homma M. Hotta H. Hepatitis C virus (HCV) isolates obtained from 25 anti-HCV antibody-positive healthy blood donors and 29 drug addicts in Chiang Mai, Thailand, were analyzed. HCV RNA was detected in 23 blood donor samples (92%) and 24 drug addict blood samples (83%) by PCR for a portion of the NS5 region. Subtype analysis revealed that HCV type 3a (HCV-3a) was the prevailing subtype (30%), which was followed in prevalence by HCV-1a (21%), -1b (13%), -3b (13%), and -6a (2%). Six (13%) of the 47 isolates showed low sequence similarities with known types and subtypes. The sequence variants could be grouped into four branches in a molecular evolutionary phylogenetic tree. 2014-08-30T02:34:56Z 2014-08-30T02:34:56Z 1994 Comparative Study 0095-1137 7814558 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3496 eng
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Hepatitis C virus (HCV) isolates obtained from 25 anti-HCV antibody-positive healthy blood donors and 29 drug addicts in Chiang Mai, Thailand, were analyzed. HCV RNA was detected in 23 blood donor samples (92%) and 24 drug addict blood samples (83%) by PCR for a portion of the NS5 region. Subtype analysis revealed that HCV type 3a (HCV-3a) was the prevailing subtype (30%), which was followed in prevalence by HCV-1a (21%), -1b (13%), -3b (13%), and -6a (2%). Six (13%) of the 47 isolates showed low sequence similarities with known types and subtypes. The sequence variants could be grouped into four branches in a molecular evolutionary phylogenetic tree.
format Comparative Study
author Apichartpiyakul C.
Chittivudikarn C.
Miyajima H.
Homma M.
Hotta H.
spellingShingle Apichartpiyakul C.
Chittivudikarn C.
Miyajima H.
Homma M.
Hotta H.
Analysis of hepatitis C virus isolates among healthy blood donors and drug addicts in Chiang Mai, Thailand
author_facet Apichartpiyakul C.
Chittivudikarn C.
Miyajima H.
Homma M.
Hotta H.
author_sort Apichartpiyakul C.
title Analysis of hepatitis C virus isolates among healthy blood donors and drug addicts in Chiang Mai, Thailand
title_short Analysis of hepatitis C virus isolates among healthy blood donors and drug addicts in Chiang Mai, Thailand
title_full Analysis of hepatitis C virus isolates among healthy blood donors and drug addicts in Chiang Mai, Thailand
title_fullStr Analysis of hepatitis C virus isolates among healthy blood donors and drug addicts in Chiang Mai, Thailand
title_full_unstemmed Analysis of hepatitis C virus isolates among healthy blood donors and drug addicts in Chiang Mai, Thailand
title_sort analysis of hepatitis c virus isolates among healthy blood donors and drug addicts in chiang mai, thailand
publishDate 2014
url http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3496
_version_ 1681420059210153984

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