Ifosfamide, epirubicin and cisplatin (IEP): another active combination for small cell lung cancer (SCLC)

Sixty-four SCLC patients (44 males and 20 females, median age 60 years, median PS 60%) were treated with an IEP regimen. Forty-nine cases were evaluable, 35 cases were limited disease (LD) and 14 cases were extensive disease (ED). Treatment consisted of ifosfamide 1.5 g/m2 i.v. infusion for 4 h on d...

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Main Authors: Thongprasert S., Jiamsriponges K.
Format: Article
Language:English
Published: 2014
Online Access:http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3518
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Institution: Chiang Mai University
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spelling th-cmuir.6653943832-35182014-08-30T02:34:58Z Ifosfamide, epirubicin and cisplatin (IEP): another active combination for small cell lung cancer (SCLC) Thongprasert S. Jiamsriponges K. Sixty-four SCLC patients (44 males and 20 females, median age 60 years, median PS 60%) were treated with an IEP regimen. Forty-nine cases were evaluable, 35 cases were limited disease (LD) and 14 cases were extensive disease (ED). Treatment consisted of ifosfamide 1.5 g/m2 i.v. infusion for 4 h on days 1 and 2 with mesna uroprotection; epirubicin 60 mg/m2 i.v. on day 1; and cis-platin 60 mg/m2 i.v. infusion over 2 h on day 3; repeated treatment every 4 weeks. Eighty percent response rate (95% confidence limit = 66.75% to 93.25%) was seen in LD with 22.8% CR. In ED, total response rate was 85.7% (95% confidence limit = 67.36% to 104.04%) with 21.4% CR. One-year survival of LD was 45.5% and ED was 17.6%. Treatment toxicity was moderate. Most common toxic effects included alopecia, leukopenia (28.5% grade 3, 14.3% grade 4) nausea and vomiting (50% grade 2, 15% grade 3) and anemia (26.5% grade 3 and 4). Addition of thoracic radiotherapy after complete chemotherapy (only CR and PR in LD cases) was a good prognostic factor. These results suggest that IEP regimen is one of the active combination for SCLC. The dosage of IEP in this study caused moderate toxicity. 2014-08-30T02:34:58Z 2014-08-30T02:34:58Z 1993 Journal Article 0169-5002 8069608 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3518 eng
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Sixty-four SCLC patients (44 males and 20 females, median age 60 years, median PS 60%) were treated with an IEP regimen. Forty-nine cases were evaluable, 35 cases were limited disease (LD) and 14 cases were extensive disease (ED). Treatment consisted of ifosfamide 1.5 g/m2 i.v. infusion for 4 h on days 1 and 2 with mesna uroprotection; epirubicin 60 mg/m2 i.v. on day 1; and cis-platin 60 mg/m2 i.v. infusion over 2 h on day 3; repeated treatment every 4 weeks. Eighty percent response rate (95% confidence limit = 66.75% to 93.25%) was seen in LD with 22.8% CR. In ED, total response rate was 85.7% (95% confidence limit = 67.36% to 104.04%) with 21.4% CR. One-year survival of LD was 45.5% and ED was 17.6%. Treatment toxicity was moderate. Most common toxic effects included alopecia, leukopenia (28.5% grade 3, 14.3% grade 4) nausea and vomiting (50% grade 2, 15% grade 3) and anemia (26.5% grade 3 and 4). Addition of thoracic radiotherapy after complete chemotherapy (only CR and PR in LD cases) was a good prognostic factor. These results suggest that IEP regimen is one of the active combination for SCLC. The dosage of IEP in this study caused moderate toxicity.
format Article
author Thongprasert S.
Jiamsriponges K.
spellingShingle Thongprasert S.
Jiamsriponges K.
Ifosfamide, epirubicin and cisplatin (IEP): another active combination for small cell lung cancer (SCLC)
author_facet Thongprasert S.
Jiamsriponges K.
author_sort Thongprasert S.
title Ifosfamide, epirubicin and cisplatin (IEP): another active combination for small cell lung cancer (SCLC)
title_short Ifosfamide, epirubicin and cisplatin (IEP): another active combination for small cell lung cancer (SCLC)
title_full Ifosfamide, epirubicin and cisplatin (IEP): another active combination for small cell lung cancer (SCLC)
title_fullStr Ifosfamide, epirubicin and cisplatin (IEP): another active combination for small cell lung cancer (SCLC)
title_full_unstemmed Ifosfamide, epirubicin and cisplatin (IEP): another active combination for small cell lung cancer (SCLC)
title_sort ifosfamide, epirubicin and cisplatin (iep): another active combination for small cell lung cancer (sclc)
publishDate 2014
url http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3518
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