The long-term growth and development of children exposed to Depo-Provera during pregnancy or lactation

Children exposed to the injectable contraceptive Depo-Provera (DMPA) during pregnancy (N = 1,207), and/or during breastfeeding (N = 1,215) were exposures during pregnancy or breastfeeding. Weights and heights were measured for all children, and information on signs of puberty obtained for children a...

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Main Authors: Pardthaisong T., Yenchit C., Gray R.
Format: Article
Language:English
Published: 2014
Online Access:http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3548
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-35482014-08-30T02:35:01Z The long-term growth and development of children exposed to Depo-Provera during pregnancy or lactation Pardthaisong T. Yenchit C. Gray R. Children exposed to the injectable contraceptive Depo-Provera (DMPA) during pregnancy (N = 1,207), and/or during breastfeeding (N = 1,215) were exposures during pregnancy or breastfeeding. Weights and heights were measured for all children, and information on signs of puberty obtained for children aged ten and over. Cross-sectional weights and heights by age of DMPA-exposed children were similar to those for controls. Children with DMPA exposure during pregnancy and lactation had an increased risk of suboptimal growth in height, defined as less than two Z scores on NCHS standards (RR = 1.4, 95% CI 1.2-1.8). However, after adjustment for socioeconomic factors by multiple logistic regression, there was no increased risk of impaired growth among the DMPA-exposed children (RR = 1.1, 95% CI 0.8 - 1.6). With the exception of a delay in onset of reported pubic hair growth among DMPA-exposed girls, there were no significant effects on attainment of puberty. We conclude that use of DMPA during pregnancy or breastfeeding does not adversely affect the long-term growth and development of children. 2014-08-30T02:35:01Z 2014-08-30T02:35:01Z 1992 Journal Article 0010-7824 1387602 http://www.ncbi.nlm.nih.gov/pubmed/3502482 http://cmuir.cmu.ac.th/handle/6653943832/3548 eng
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Children exposed to the injectable contraceptive Depo-Provera (DMPA) during pregnancy (N = 1,207), and/or during breastfeeding (N = 1,215) were exposures during pregnancy or breastfeeding. Weights and heights were measured for all children, and information on signs of puberty obtained for children aged ten and over. Cross-sectional weights and heights by age of DMPA-exposed children were similar to those for controls. Children with DMPA exposure during pregnancy and lactation had an increased risk of suboptimal growth in height, defined as less than two Z scores on NCHS standards (RR = 1.4, 95% CI 1.2-1.8). However, after adjustment for socioeconomic factors by multiple logistic regression, there was no increased risk of impaired growth among the DMPA-exposed children (RR = 1.1, 95% CI 0.8 - 1.6). With the exception of a delay in onset of reported pubic hair growth among DMPA-exposed girls, there were no significant effects on attainment of puberty. We conclude that use of DMPA during pregnancy or breastfeeding does not adversely affect the long-term growth and development of children.
format Article
author Pardthaisong T.
Yenchit C.
Gray R.
spellingShingle Pardthaisong T.
Yenchit C.
Gray R.
The long-term growth and development of children exposed to Depo-Provera during pregnancy or lactation
author_facet Pardthaisong T.
Yenchit C.
Gray R.
author_sort Pardthaisong T.
title The long-term growth and development of children exposed to Depo-Provera during pregnancy or lactation
title_short The long-term growth and development of children exposed to Depo-Provera during pregnancy or lactation
title_full The long-term growth and development of children exposed to Depo-Provera during pregnancy or lactation
title_fullStr The long-term growth and development of children exposed to Depo-Provera during pregnancy or lactation
title_full_unstemmed The long-term growth and development of children exposed to Depo-Provera during pregnancy or lactation
title_sort long-term growth and development of children exposed to depo-provera during pregnancy or lactation
publishDate 2014
url http://www.ncbi.nlm.nih.gov/pubmed/3502482
http://cmuir.cmu.ac.th/handle/6653943832/3548
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