Growth Hormone (GH)-dependent expression of a natural antisense transcript induces zinc finger E-box-binding homeobox 2 (ZEB2) in the glomerular podocyte: A novel action of GH with implications for the pathogenesis of diabetic nephropathy

• Main Authors: Kumar P.A., Kotlyarevska K., Dejkhmaron P., Reddy G.R., Lu C., Bhojani M.S., Menon R.K.
• Format: Article
• Language: English
• Published: 2014
• Online Access: http://www.scopus.com/inward/record.url?eid=2-s2.0-77957759709&partnerID=40&md5=c6dfc719444faa865acb09e4e7e568b5; http://cmuir.cmu.ac.th/handle/6653943832/3625
• Institution: Chiang Mai University

Growth hormone (GH) excess results in structural and functional changes in the kidney and is implicated as a causative factor in the development of diabetic nephropathy (DN). Glomerular podocytes are the major barrier to the filtration of serum proteins, and altered podocyte function and/or reduced...