Effect of bitter melon (Momordica Charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy

Cervical cancer patients have a defective immune system. There is a decrease of total white blood cell count including lymphocytes and natural killer (NK) cells. NK cells, one type of lymphocytes, play a role to eliminate cancer cells by antibody dependent cell mediated cytotoxicity (ADCC) mechanism...

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Main Authors: Pongnikorn S., Kasinrerk W., Fongmoon D., Limtrakul P.-N.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-0037271368&partnerID=40&md5=f5316399670da65a3617c3b8a0a9a342
http://cmuir.cmu.ac.th/handle/6653943832/3628
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spelling th-cmuir.6653943832-36282014-08-30T02:35:08Z Effect of bitter melon (Momordica Charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy Pongnikorn S. Kasinrerk W. Fongmoon D. Limtrakul P.-N. Cervical cancer patients have a defective immune system. There is a decrease of total white blood cell count including lymphocytes and natural killer (NK) cells. NK cells, one type of lymphocytes, play a role to eliminate cancer cells by antibody dependent cell mediated cytotoxicity (ADCC) mechanism. Previous studies have shown that P-glycoprotein (170 kDa, transmembrane protein) may be a transporter for cytokine releasing in ADCC mechanism. This study proposed to explore the role of bitter melon intake in cervical cancer patients undergoing normal treatment (radiotherapy). Subjects were divided into three groups: 1) normal control (women 35-55 years, n = 35), 2) patient control (n = 30) and 3) patient treatment (n = 30) groups. Patient control and patient treatment groups were cervical cancer patients (stage II or III) treated with radiotherapy (without or with bitter melon ingestion). Blood samples of patient control and patient treatment groups were analyzed for NK cells percentage and P-glycoprotein level. Bitter melon is a Thai herb. Previous studies have shown that bitter melon can stimulate lymphocyte activity in vitro and in vivo (mouse). The authors hope that bitter melon could stimulate the increase of NK cells percentage and P-glycoprotein level on the membrane in blood samples from cervical cancer patients who ingest bitter melon. The results showed an increased percentage of NK cells in patient control and patient treatment groups. The increase in each group is significant (p < 0.05) when compared with the percentage of NK cells from second and third blood sampling time (after radiation with of without bitter melon intake for 45 and 90 days) with first blood sampling time (before treatment). The results also show a significant decrease of P-glycoprotein level (p < 0.05) in second and third blood sampling times when compared with first blood sampling time of the patient treatment group. There was no significant difference of P-glycoprotein (P-gp) level from first, second and third blood sampling times in patient control group. Bitter melon ingestion did not affect NK cell level but it affected the decrease of P-gp level on NK cell membrane. 2014-08-30T02:35:08Z 2014-08-30T02:35:08Z 2003 Article 01252208 12678140 JMTHB http://www.scopus.com/inward/record.url?eid=2-s2.0-0037271368&partnerID=40&md5=f5316399670da65a3617c3b8a0a9a342 http://cmuir.cmu.ac.th/handle/6653943832/3628 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description Cervical cancer patients have a defective immune system. There is a decrease of total white blood cell count including lymphocytes and natural killer (NK) cells. NK cells, one type of lymphocytes, play a role to eliminate cancer cells by antibody dependent cell mediated cytotoxicity (ADCC) mechanism. Previous studies have shown that P-glycoprotein (170 kDa, transmembrane protein) may be a transporter for cytokine releasing in ADCC mechanism. This study proposed to explore the role of bitter melon intake in cervical cancer patients undergoing normal treatment (radiotherapy). Subjects were divided into three groups: 1) normal control (women 35-55 years, n = 35), 2) patient control (n = 30) and 3) patient treatment (n = 30) groups. Patient control and patient treatment groups were cervical cancer patients (stage II or III) treated with radiotherapy (without or with bitter melon ingestion). Blood samples of patient control and patient treatment groups were analyzed for NK cells percentage and P-glycoprotein level. Bitter melon is a Thai herb. Previous studies have shown that bitter melon can stimulate lymphocyte activity in vitro and in vivo (mouse). The authors hope that bitter melon could stimulate the increase of NK cells percentage and P-glycoprotein level on the membrane in blood samples from cervical cancer patients who ingest bitter melon. The results showed an increased percentage of NK cells in patient control and patient treatment groups. The increase in each group is significant (p < 0.05) when compared with the percentage of NK cells from second and third blood sampling time (after radiation with of without bitter melon intake for 45 and 90 days) with first blood sampling time (before treatment). The results also show a significant decrease of P-glycoprotein level (p < 0.05) in second and third blood sampling times when compared with first blood sampling time of the patient treatment group. There was no significant difference of P-glycoprotein (P-gp) level from first, second and third blood sampling times in patient control group. Bitter melon ingestion did not affect NK cell level but it affected the decrease of P-gp level on NK cell membrane.
format Article
author Pongnikorn S.
Kasinrerk W.
Fongmoon D.
Limtrakul P.-N.
spellingShingle Pongnikorn S.
Kasinrerk W.
Fongmoon D.
Limtrakul P.-N.
Effect of bitter melon (Momordica Charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy
author_facet Pongnikorn S.
Kasinrerk W.
Fongmoon D.
Limtrakul P.-N.
author_sort Pongnikorn S.
title Effect of bitter melon (Momordica Charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy
title_short Effect of bitter melon (Momordica Charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy
title_full Effect of bitter melon (Momordica Charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy
title_fullStr Effect of bitter melon (Momordica Charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy
title_full_unstemmed Effect of bitter melon (Momordica Charantia Linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy
title_sort effect of bitter melon (momordica charantia linn) on level and function of natural killer cells in cervical cancer patients with radiotherapy
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-0037271368&partnerID=40&md5=f5316399670da65a3617c3b8a0a9a342
http://cmuir.cmu.ac.th/handle/6653943832/3628
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