Cadmium induced renal dysfunction among residents of rice farming area downstream from a zinc-mineralized belt in Thailand

High levels of cadmium (Cd) in paddy soil and rice, and a concurrent increase in urinary Cd of inhabitants in the Mae Sot District, Tak Province, Thailand first emerged in 2003. Risk factors such as occupation, sources of staple food and drinking water as well as biomarkers of adverse renal effects...

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Main Authors: Honda R., Swaddiwudhipong W., Nishijo M., Mahasakpan P., Teeyakasem W., Ruangyuttikarn W., Satarug S., Padungtod C., Nakagawa H.
Format: Article
Language:English
Published: 2014
Online Access:http://www.scopus.com/inward/record.url?eid=2-s2.0-77955657995&partnerID=40&md5=3eafef096319b270ef392f96e5fdceeb
http://cmuir.cmu.ac.th/handle/6653943832/3636
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Institution: Chiang Mai University
Language: English
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spelling th-cmuir.6653943832-36362014-08-30T02:35:08Z Cadmium induced renal dysfunction among residents of rice farming area downstream from a zinc-mineralized belt in Thailand Honda R. Swaddiwudhipong W. Nishijo M. Mahasakpan P. Teeyakasem W. Ruangyuttikarn W. Satarug S. Padungtod C. Nakagawa H. High levels of cadmium (Cd) in paddy soil and rice, and a concurrent increase in urinary Cd of inhabitants in the Mae Sot District, Tak Province, Thailand first emerged in 2003. Risk factors such as occupation, sources of staple food and drinking water as well as biomarkers of adverse renal effects of the increased body burden of Cd were investigated in 795 residents, 30 years or older, whose urinary Cd levels were between 0.02 and 106μg/g creatinine. Farmers who consumed their own rice and residents who sourced drinking water from wells and/or the river demonstrated increased urinary Cd. Age-adjusted mean urinary cadmium for male and female subjects who consumed well water was 5.7μg/g vs. 6.1μg/g creatinine while the corresponding value for male and female subjects who did not consume well water was 3.7μg/g vs. 4.8μg/g creatinine, respectively. Increased urinary levels of β2-microglobulin and N-acetyl-β-d-glucosaminidase were observed with the increase in urinary Cd, indicating tubular dysfunction and renal damage associated with increase in Cd body burden. Consumption of well water and rice grown in the contaminated area increase the body burden of Cd. Cessation of exposure is essential to prevent and possibly recover from Cd toxicity, especially among the residents whose kidney damage and malfunction may be reversible. © 2010 Elsevier Ireland Ltd. 2014-08-30T02:35:08Z 2014-08-30T02:35:08Z 2010 Article 3784274 10.1016/j.toxlet.2010.04.023 20435107 TOLED http://www.scopus.com/inward/record.url?eid=2-s2.0-77955657995&partnerID=40&md5=3eafef096319b270ef392f96e5fdceeb http://cmuir.cmu.ac.th/handle/6653943832/3636 English
institution Chiang Mai University
building Chiang Mai University Library
country Thailand
collection CMU Intellectual Repository
language English
description High levels of cadmium (Cd) in paddy soil and rice, and a concurrent increase in urinary Cd of inhabitants in the Mae Sot District, Tak Province, Thailand first emerged in 2003. Risk factors such as occupation, sources of staple food and drinking water as well as biomarkers of adverse renal effects of the increased body burden of Cd were investigated in 795 residents, 30 years or older, whose urinary Cd levels were between 0.02 and 106μg/g creatinine. Farmers who consumed their own rice and residents who sourced drinking water from wells and/or the river demonstrated increased urinary Cd. Age-adjusted mean urinary cadmium for male and female subjects who consumed well water was 5.7μg/g vs. 6.1μg/g creatinine while the corresponding value for male and female subjects who did not consume well water was 3.7μg/g vs. 4.8μg/g creatinine, respectively. Increased urinary levels of β2-microglobulin and N-acetyl-β-d-glucosaminidase were observed with the increase in urinary Cd, indicating tubular dysfunction and renal damage associated with increase in Cd body burden. Consumption of well water and rice grown in the contaminated area increase the body burden of Cd. Cessation of exposure is essential to prevent and possibly recover from Cd toxicity, especially among the residents whose kidney damage and malfunction may be reversible. © 2010 Elsevier Ireland Ltd.
format Article
author Honda R.
Swaddiwudhipong W.
Nishijo M.
Mahasakpan P.
Teeyakasem W.
Ruangyuttikarn W.
Satarug S.
Padungtod C.
Nakagawa H.
spellingShingle Honda R.
Swaddiwudhipong W.
Nishijo M.
Mahasakpan P.
Teeyakasem W.
Ruangyuttikarn W.
Satarug S.
Padungtod C.
Nakagawa H.
Cadmium induced renal dysfunction among residents of rice farming area downstream from a zinc-mineralized belt in Thailand
author_facet Honda R.
Swaddiwudhipong W.
Nishijo M.
Mahasakpan P.
Teeyakasem W.
Ruangyuttikarn W.
Satarug S.
Padungtod C.
Nakagawa H.
author_sort Honda R.
title Cadmium induced renal dysfunction among residents of rice farming area downstream from a zinc-mineralized belt in Thailand
title_short Cadmium induced renal dysfunction among residents of rice farming area downstream from a zinc-mineralized belt in Thailand
title_full Cadmium induced renal dysfunction among residents of rice farming area downstream from a zinc-mineralized belt in Thailand
title_fullStr Cadmium induced renal dysfunction among residents of rice farming area downstream from a zinc-mineralized belt in Thailand
title_full_unstemmed Cadmium induced renal dysfunction among residents of rice farming area downstream from a zinc-mineralized belt in Thailand
title_sort cadmium induced renal dysfunction among residents of rice farming area downstream from a zinc-mineralized belt in thailand
publishDate 2014
url http://www.scopus.com/inward/record.url?eid=2-s2.0-77955657995&partnerID=40&md5=3eafef096319b270ef392f96e5fdceeb
http://cmuir.cmu.ac.th/handle/6653943832/3636
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